688364-76-3Relevant academic research and scientific papers
Diastereo- and enantioselective synthesis of anti-1,3-mercapto alcohols from α,β-unsaturated ketones via tandem Michael addition-MPV reduction
Ozeki, Minoru,Nishide, Kiyoharu,Teraoka, Fumiteru,Node, Manabu
, p. 895 - 907 (2004)
A new and effective asymmetric synthesis of anti-1,3-mercapto alcohols 3 from α,β-unsaturated ketones 1 utilizing tandem Michael addition-Meerwein-Ponndorf-Verley (MPV) reduction is described. Transformation of the MPV products anti-4 via the Wagner-Meerwein rearrangement was optimized under acidic or basic conditions to afford 1,3-mercapto alcohols anti-3, depending on the substituent R2 of 4.
