6884-46-4Relevant academic research and scientific papers
Synthesis and characterization of novel classes of PDE10A inhibitors - 1H-1,3-benzodiazoles and imidazo[1,2-a]pyrimidines
Moszczyński-P?tkowski, Rafa?,Majer, Jakub,Borkowska, Ma?gorzata,Bojarski, ?ukasz,Janowska, Sylwia,Mat?oka, Miko?aj,Stefaniak, Filip,Smuga, Damian,Bazyd?o, Katarzyna,Dubiel, Krzysztof,Wieczorek, Maciej
, p. 96 - 116 (2018/06/06)
New compounds containing [1,2,4]triazolo [1,5-a]pyridine (I), pyrazolo [1,5-a]pyridine (II), 1H-1,3-benzodiazole (III) and imidazo [1,2-a]pyrimidine (IV) backbones were designed and synthesized for PDE10A interaction. Among these compounds, 1H-1,3-benzodiazoles and imidazo [1,2-a]pyrimidines showed the highest affinity for PDE10A enzyme as well as good metabolic stability. Both classes of compounds were identified as selective and potent PDE10A enzyme inhibitors.
FUSED TRIAZOLE DERIVATIVES AS PHOSPHODIESTERASE 10A INHIBITORS
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Page/Page column 20; 21, (2015/12/08)
Compounds of the general formula (I), wherein one of X1 and X2 represents N, and the other one of X1 and X2 represents -C(CH3), A represents unsubstituted or substituted 5-, 6-or 10-membered aryl or h
