68873-22-3Relevant academic research and scientific papers
Versatile One-Pot Synthesis of Polysubstituted Cyclopent-2-enimines from α,β-Unsaturated Amides: Imino-Nazarov Reaction
Fan, Ting,Wang, Ao,Li, Jia-Qi,Ye, Jian-Liang,Zheng, Xiao,Huang, Pei-Qiang
supporting information, p. 10352 - 10356 (2018/07/30)
The imino-Nazarov cyclization of the polysubstituted pentan-1,4-diene-3-imines was realized. To this aim, a one-pot procedure involving reductive alkenyliminylation of α,β-unsaturated secondary amides with potassium organotrifluoroborates, followed by acid-catalyzed imino-Nazarov cyclization of the polysubstituted pentan-1,4-diene-3-imine intermediates, was studied systematically. This mild, operationally simple, flexible, and high-yielding protocol efficiently affords polysubstituted pentan-1,4-diene-3-imines, cyclopentenimines, and α-amino cyclopentenones, which are useful scaffolds in organic synthesis. The substituent effect at the C2 position of the polysubstituted pentan-1,4-diene-3-imines was studied by means of density-functional theory calculations. Results suggested that the electron-donating group facilitates the imino-Nazarov cyclization process.
A General Method for Two-Step Transamidation of Secondary Amides Using Commercially Available, Air- and Moisture-Stable Palladium/NHC (N-Heterocyclic Carbene) Complexes
Meng, Guangrong,Lei, Peng,Szostak, Michal
supporting information, p. 2158 - 2161 (2017/04/27)
The first general method is reported for transamidation of secondary carboxamides catalyzed by Pd-NHC (NHC = N-heterocyclic carbene) complexes. Commercially available, air- and moisture-stable (NHC)Pd(R-allyl)Cl complexes can effect C-N cross-coupling of a wide range of N-Boc and N-Ts amides, obtained by selective amide N-functionalization, with non-nucleophilic anilines and sterically hindered amines in very good yields. The first use of versatile Pd-NHC complexes as catalysts is represented for transition-metal-catalyzed C(acyl)-N amination of amides by N-C activation.
Copper-catalyzed oxidative amidation between aldehydes and arylamines under mild conditions
Ding, Yongzheng,Zhang, Xian,Zhang, Dongyang,Chen, Yuting,Wu, Zhibing,Wang, Peiyi,Xue, Wei,Song, Baoan,Yang, Song
supporting information, p. 831 - 833 (2015/02/19)
A facile strategy to prepare amide bonds has been developed. A series of amide compounds, including heterocyclic amide compounds, were obtained with moderate to good yields ranging from 31-88% by using copper iodide (CuI) to catalyze the oxidative amidation between aldehydes and amines under solvent-free conditions at room temperature in air.
A new method for the synthesis of substituted 3-amino-1,2,4- triazoles
Bezbarua, Maitreyee Sarma,Kataky
, p. 425 - 428 (2019/01/21)
A number of 4,5-substituted-3-amino-1,2,4-triazoles have been synthesized from different anilines. The compounds are characterized on the basis of 1H NMR and mass spectral data.
