688741-47-1Relevant academic research and scientific papers
New reactivity of nitropyrimidinone: Ring transformation and N-C transfer reactions
Nishiwaki, Nagatoshi,Matsushima, Kazuo,Chatani, Miki,Tamura, Mina,Ariga, Masahiro
, p. 703 - 707 (2004)
Nitropyrimidinone 1 revealed new reactivity upon treatment with active methylene compounds 2 under basic conditions. The N1-C2-C3-C4 moiety of 1 combined with two carbon units of 2 affording polyfunctionalized pyridones 4, which was hitherto unknown ring transformation. On the other hand, the N1-C2 moiety of 1 was transferred to the methylene group of 2 giving functionalized enamines 3. It was also possible to modify the amino group in 3a by reactions with primary amines. Enamines 3 reacted with hydrazines, and leading to functionalized pyrazoles 7 quantitatively. The ratios of regioisomeric pyrazoles 7/8 were moderately controlled by use of sterically hindered enamines 3h, 3k and 31. Furthermore, enamine 3a was readily converted to 1,4-diazepines 9 having a functional group at the 6-position.
Microwave assisted gould-jacobs reaction for synthesis of 3-acetyl-4-hydroxyquinoline derivatives
Uz Zaman, Ashhar,Ain Khan, Misbahul,Ali Munawar, Munawar,Athar, Muhammad Makshoof,Pervaiz, Muhammad,Pervaiz, Ansar,Mahmood, Ayaz
, p. 2823 - 2826 (2015/12/11)
Different types of quinoline derivatives have been synthesized by microwave irradiation and reaction yields were compared with reported classical methodology. The emphasis on this research project was to reduce reaction times and enhance the yields of the
