68884-32-2

Usage

InChI:InChI=1/C13H12O/c1-2-7-13-10(4-1)5-3-6-11(13)8-12-9-14-12/h1-7,12H,8-9H2

Upstream product

• 90-11-9 1-Bromonaphthalene 
• 120727-54-0 1-chloro-3-[1]naphthyl-propan-2-ol 
• 703-55-9 1-naphthylmagnesiumbromide 
• 2489-86-3 1-allylnaphthalene 

Downstream Products

• 145771-05-7 2-hydroxy-3-(1-naphthyl)-1-[1-(4-phenylpiperidinyl)]propane 
• 2489-86-3 1-allylnaphthalene 
• 27653-22-1 3-(Naphth-1-yl)propan-1-ol 

Relevant academic research and scientific papers

Stereospecific Deoxygenation of Aliphatic Epoxides to Alkenes under Rhenium Catalysis

The combination of a catalytic amount of Re2O7 and triphenyl phosphite as a reductant is effective for the deoxygenation of unactivated aliphatic epoxides to alkenes. The reaction proceeds stereospecifically with variously substituted epoxides under neutral conditions and is compatible with various functional groups. Protection and deprotection of a double bond functionality using an epoxide are shown as an example of the current rhenium-catalyzed deoxygenation protocol. The effect of reductants for the stereoselectivity has also been studied, indicating that the use of electron-deficient phosphines or phosphites is the key for the stereospecific deoxygenation. (Chemical Equation Presented).

Synthesis and structure of some aryl-substituted thiiranes

A number of aryl-substituted 1,2-chlorohydrins was prepared by treating 1,2-epoxy-3-chloropropane with arylmagnesium bromide. The reaction of the aryl-substituted 1,2-chlorohydrins with sodium hydroxide solution furnished the corresponding oxiranes, the k

Synthesis and study of the lubricating properties of some thiiranes

A series of novel thiiranes were synthesized, and their lubricating properties were studied. It has been found that they improve the antiscuff and antiwear properties of gear oils and therefore can be used as additives. The relation between the structure of the synthesized thiiranes and their lubricating activity was revealed.

Acyclic analogues of 2-(4-phenylpiperidino)cyclohexanol (vesamicol): Conformationally mobile inhibitors of vesicular acetylcholine transport

Several 1,3-disubstituted propan-2-ols and one α,β-disubstituted ethanol (11i) were synthesized and evaluated as potential acyclic mimics of the vesicular acetylcholine transport inhibitor 2-(4-phenylpiperidinyl)cyclohexanol (1, vesamicol, AH5183). Analogues containing the 4-phenylpiperidyl fragment (11a, 11b) were more potent than those containing the 4-phenylpiperazyl moiety (11e, 11f). Substitution at the second terminal carbon of the propyl (or ethyl) fragment with simple lipophilic aryl substituents yielded potent inhibitors of vesicular acetylcholine storage, including (-)-11a and d-11i, which are equipotent with vesamicol. However, the activity of analogues containing bicyclic aryl groups was susceptible to aryl substitution patterns (11g vs 11h), indicating a definite receptor site topography. In addition, the inhibitory activity of these acyclic analogues was enantioselective, exhibiting a preference, similar to the parent vesamicol, for the levorotatory isomer [(-)-11a vs (+)-11a]. Therefore, the simple lipophilic acyclic vicinal amino alcohols may successfully mimic the biological activity of vesamicol.