68887-67-2Relevant articles and documents
Bifunctional small molecule compound capable of activating enzyme catalytic reaction, and applications thereof
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Paragraph 0066-0068; 0072; 0075-0081; 0082-0086, (2019/10/01)
The present invention relates to a catalytic reaction, particularly to a bifunctional small molecule compound capable of activating an enzyme catalytic reaction, and applications thereof, wherein thebifunctional small molecule compound is C5-10 carboxylic acid, C5-10 fluorocarboxylic acid, aromatic heterocyclic ring substituted carboxylic acid, heterocyclic ring substituted carboxylic acid, a C5-10 carboxylic acid amide derivative, a C5-10 fluorocarboxylic acid amide derivative, an aromatic heterocyclic ring substituted carboxylic acid amide derivative or a heterocyclic ring substituted carboxylic acid amide derivative substituted with at least a catalytic group, wherein the carboxyl group or the amide derivative is used as an anchoring group. According to the present invention, with themethod, the number of the introduced catalytic groups cannot be limited, and the orientation of the catalytic functional group and the fine adjustment of the distance from the active center can be achieved, such that the H2O2 activation efficiency can be well enhanced, and the catalytic activity and the stereoselectivity can be improved.
Development of imidazole alkanoic acids as mGAT3 selective GABA uptake inhibitors
Hack, Silke,W?rlein, Babette,H?fner, Georg,Pabel, J?rg,Wanner, Klaus T.
experimental part, p. 1483 - 1498 (2011/05/11)
A new series of potential GABA uptake inhibitors starting from of 1H-imidazol-4-ylacetic acid with the carboxylic acid side chain originating from different positions and varying in length have been synthesized and tested for the inhibitory potency at the
