6890-08-0

Basic information

• Product Name: 2-HYDROXYISOQUINOLINE-1,3(2H,4H)-DIONE
• Synonyms: 2-HYDROXYISOQUINOLINE-1,3(2H,4H)-DIONE;2-HYDROXY-1,3(2H,4H)-ISOQUINOLINEDIONE
• CAS NO: 6890-08-0
• Molecular Formula: C9H7NO3
• Molecular Weight: 177.158
• Product Categories: Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 6890-08-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 197-200°C
• Boiling Point: 382.7°C at 760 mmHg
• Flash Point: 185.3°C
• Appearance: /
• Density: 1.51g/cm³
• Vapor Pressure: 1.53E-06mmHg at 25°C
• Refractive Index: 1.67
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 2-HYDROXYISOQUINOLINE-1,3(2H,4H)-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXYISOQUINOLINE-1,3(2H,4H)-DIONE(6890-08-0)
• EPA Substance Registry System: 2-HYDROXYISOQUINOLINE-1,3(2H,4H)-DIONE(6890-08-0)

Safety Data

• Hazardous Substances Data: 6890-08-0(Hazardous Substances Data)

Usage

Uses

Used in Antiviral Applications:
2-Hydroxyisoquinoline-1,3(2H,4H)-dione is used as an antiviral agent, specifically targeting the inhibition of HIV-1 integrase and the RNase H function of HIV-1 reverse transcriptase. This makes it a promising candidate for the development of new antiviral therapies against HIV-1.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Hydroxyisoquinoline-1,3(2H,4H)-dione is used as a chemical scaffold for the development of new antiviral drugs. Its unique interaction with Mg2+ and Mn2+ ions, as well as its ability to inhibit key enzymes involved in the replication of HIV-1, make it a valuable compound for further research and drug development efforts.

InChI:InChI=1/C9H7NO3/c11-8-5-6-3-1-2-4-7(6)9(12)10(8)13/h1-4,13H,5H2

Upstream product

• 611187-05-4 2-benzyloxyisoquinoline-1,3(2H,4H)-dione 
• 703-59-3 homophthalic anhydride 
• 2446-51-7 N-methoxybenzamide 
• 22367-15-3 2-methoxyisoquinoline-1,3(2H,4H)-dione 
• 89-51-0 Homophthalic acid 

Relevant articles and documents

4-benzylideneisoquinoline-1,3(2H,4H)-diones as tyrosyl DNA phosphodiesterase 2 (TDP2) inhibitors

Tyrosyl-DNA phosphodiesterase 2 (TDP2) repairs topoisomerase II (Top2) mediated DNA damages, including double-strand breaks (DSBs) that underpin the anticancer mechanism of clinical Top2 poisons such as etoposide (ETP). Inhibition of TDP2 could sensitize

Method for selection of hDIS3 PIN domain inhibitors and use of hDIS3 PIN domain inhibitors for cancer treatment

The present invention relates to a method for selection or screening of hDIS3 PIN domain inhibitors, yeast strain and cell line used in such methods It also relates to new therapeutic agents selected hDIS3 PIN domain inhibitors and uses thereof in the tre

Design, synthesis, and biological evaluation of a series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as dual inhibitors of human immunodeficiency virus type 1 integrase and the reverse transcriptase RNase H domain

We report herein the synthesis of a series of 19 2-hydroxyisoquinoline-1, 3(2H,4H)-dione derivatives variously substituted at position 7 aimed at inhibiting selectively two-metal ion catalytic active sites. The compounds were tested against HIV-1 reverse