6890-08-0

Basic information

• Product Name: 2-HYDROXYISOQUINOLINE-1,3(2H,4H)-DIONE
• Synonyms: 2-HYDROXYISOQUINOLINE-1,3(2H,4H)-DIONE;2-HYDROXY-1,3(2H,4H)-ISOQUINOLINEDIONE
• CAS NO: 6890-08-0
• Molecular Formula: C9H7NO3
• Molecular Weight: 177.158
• Product Categories: Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 6890-08-0.mol

Chemical Properties

• Melting Point: 197-200°C
• Boiling Point: 382.7°C at 760 mmHg
• Flash Point: 185.3°C
• Appearance: /
• Density: 1.51g/cm³
• Vapor Pressure: 1.53E-06mmHg at 25°C
• Refractive Index: 1.67
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 2-HYDROXYISOQUINOLINE-1,3(2H,4H)-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXYISOQUINOLINE-1,3(2H,4H)-DIONE(6890-08-0)
• EPA Substance Registry System: 2-HYDROXYISOQUINOLINE-1,3(2H,4H)-DIONE(6890-08-0)

Safety Data

• Hazardous Substances Data: 6890-08-0(Hazardous Substances Data)

Usage

Uses

Used in Antiviral Applications:
2-Hydroxyisoquinoline-1,3(2H,4H)-dione is used as an antiviral agent, specifically targeting the inhibition of HIV-1 integrase and the RNase H function of HIV-1 reverse transcriptase. This makes it a promising candidate for the development of new antiviral therapies against HIV-1.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Hydroxyisoquinoline-1,3(2H,4H)-dione is used as a chemical scaffold for the development of new antiviral drugs. Its unique interaction with Mg2+ and Mn2+ ions, as well as its ability to inhibit key enzymes involved in the replication of HIV-1, make it a valuable compound for further research and drug development efforts.

InChI:InChI=1/C9H7NO3/c11-8-5-6-3-1-2-4-7(6)9(12)10(8)13/h1-4,13H,5H2

Upstream product

• 611187-05-4 2-benzyloxyisoquinoline-1,3(2H,4H)-dione 
• 89-51-0 Homophthalic acid 
• 22367-15-3 2-methoxyisoquinoline-1,3(2H,4H)-dione 
• 2446-51-7 N-methoxybenzamide 
• 703-59-3 homophthalic anhydride 

Relevant articles and documents

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Design, synthesis, and biological evaluation of a series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as dual inhibitors of human immunodeficiency virus type 1 integrase and the reverse transcriptase RNase H domain

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