68905-61-3

Basic information

• Product Name: 4-{[1-(naphthalen-1-yloxy)-3-(propan-2-ylamino)propan-2-yl]oxy}-4-oxobutanoic acid
• CAS NO: 68905-61-3
• Molecular Formula: C₂₀H₂₅NO₅
• Molecular Weight: 359.4162
• Mol File: 68905-61-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 553.5°C at 760 mmHg
• Flash Point: 288.5°C
• Density: 1.183g/cm³
• Vapor Pressure: 4.37E-13mmHg at 25°C
• Refractive Index: 1.567
• CAS DataBase Reference: 4-{[1-(naphthalen-1-yloxy)-3-(propan-2-ylamino)propan-2-yl]oxy}-4-oxobutanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-{[1-(naphthalen-1-yloxy)-3-(propan-2-ylamino)propan-2-yl]oxy}-4-oxobutanoic acid(68905-61-3)
• EPA Substance Registry System: 4-{[1-(naphthalen-1-yloxy)-3-(propan-2-ylamino)propan-2-yl]oxy}-4-oxobutanoic acid(68905-61-3)

Safety Data

• Hazardous Substances Data: 68905-61-3(Hazardous Substances Data)

Upstream product

• 1318259-33-4 PSA 
• 1318259-41-4 PSH 
• 1318259-39-0 PSN 

Relevant articles and documents

Synthesis and hydrolysis kinetic study of few co-drugs of propranolol and other antihypertensive drugs

The different acyl halide analogs of propranolol were synthesized by reacting Propanolol with different acyl anhydrides in toluene medium. The derivatives were reacted with thionyl chloride to get propranolol hemi acyl chloride. Finally the co-drugs were synthesized by reacting propranolol hemi acyl chloride with different classes of antihypertensive drugs like Nifedepine (PSN,PMN,PPN), Hydrochlorthiazide (PSH, PMH, PPH) and Acetazolamide(PSA, PMA, PPA) by ester linkage. The structure of the synthesized derivative of propranolol analogs were confirmed by M P, TLC, IR and NMR data.