6891-55-0

Upstream product

• 67409-10-3 ethyl (E)-3-(3,4-dimethoxyphenyl)-2-butenoate 
• 1131-62-0 1-(3,4-dimethoxyphenyl)ethanone 
• 5396-64-5 methyl (E)-3-(3,4-dimethoxyphenyl)acrylate 
• 15818-13-0 diethyl 2-(3,4-dimethoxybenzylidene)malonate 
• 40878-19-1 Ethyl 3-cyano-3-(3,4-dimethoxyphenyl)propionate 
• 147471-10-1 4-(3’,4’-dimethoxyphenyl)-1H-pyrrol-2(5H)-one 

Downstream Products

• 65283-73-0 4-(3,4-dimethoxyphenyl)-2-pyrrolidone-1-carboxylic acid amide 
• 121174-51-4 4-(3,4-dimethoxyphenyl)-1-phenyl-2-pyrrolidone 
• 121174-49-0 4-(3,4-dimethoxyphenyl)-1-methyl-2-pyrrolidone 

Relevant academic research and scientific papers

(Imidazolylphenyl)pyrrol-2-one inhibitors of cardiac cAMP phosphodiesterase

Seven 3-alkyl-4-aryl-1,5-dihydro-2H-pyrrol-2-ones were prepared as potential inhibitors of cardiac cAMP phosphodiesterase (PDE). The design of these compounds made use of rolipram, a known inhibitor of the brain cAMP PDE isozyme, as a lead structure and w

Inhibition of cyclic adenosine-3',5'-monophosphate phosphodiesterase from vascular smooth muscle by rolipram analogues

Rolipram [(R,S)-4-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidone] has been shown to inhibit selectively the cAMP phopshodiesterase (PDE) of vascular smooth muscle. In order to further explore the structural requirements for selective PDE inhibition, we synthesized a series of rolipram derivatives differently substituted either at the pyrrolidinone or at the aromatic ring. Among these compounds, rolipram was the most active compound. Semirigid analogues were prepared and used for an evaluation of the active conformation of rolipram. Structural comparison with two other potent and chemically different smooth muscle cAMP-PDE inhibitors, trequinsin and Ro 20-1724, allows us to propose a first topological model of the smooth muscle cAMP-PDE pharmacophore.

4-(Polyalkoxy phenyl)-2-pyrrolidones

4-(Polyalkoxyphenyl)-2-pyrrolidones of the formula STR1 wherein R1 and R2 each are hydrocarbon of up to 18 carbon atoms at least one being other than methyl, a heterocyclic ring, or alkyl of 1-5 carbon atoms substituted by halogen, OH, COOH, alkoxy, alkoxycarbonyl or an amino group; R' is H, alkyl, aryl or acyl; and X is O or S; possess neuropsychotropic activity. The compounds wherein X is O can be produced by saponifying and decarboxylating a corresponding 2-pyrrolidone-3-carboxylic acid alkyl ester or cyclizing a corresponding 3-phenyl-4-amino-butyric acid or alkyl ester thereof. The pyrrolidones can be converted to the corresponding thiopyrrolidones by reaction with phosphorous pentasulfide in the presence of base.

4-(Polyalkoxyphenyl)-2-pyrrolidones

4-(Polyalkoxyphenyl)-2-pyrrolidones of the formula STR1 wherein R1 and R2 each are hydrocarbon of up to 18 carbon atoms or alkyl of 1-5 carbon atoms substituted by halogen, OH, COOH, alkoxy, alkoxycarbonyl, carboxamido or amino or co