689260-02-4Relevant academic research and scientific papers
A convenient synthesis of 4-trifluoromethyl-(2H)-pyridazin-3-ones from methyl 3,3,3-trifluoropyruvate
Sibgatulin, Dmitriy A.,Volochnyuk, Dmitriy M.,Kostyuk, Alexandr N.
, p. 1907 - 1911 (2007/10/03)
A convenient two-step synthesis of 4-CF3-(2H)-pyridazin-3-ones starting from methyl 3,3,3-trifluoropyruvate (MeTFP) and carbonyl compounds has been elaborated. As a result, a set of various 4-CF3-(2H)-pyridazin- 3-ones was obtained.
Novel and convenient aldolization of methyl 3,3,3-trifluoropyruvate using enamines instead of ketones
Palecek, Jiri,Paleta, Oldrich
, p. 521 - 524 (2007/10/03)
Piperidine enamines derived from acetone, acetophenone, cyclopentanone and cyclohexanone react easily in minutes with methyl 3,3,3-trifluoropyruvate (1) to afford products of the aldol condensation in high yields at room temperature, which is in contrast to the direct aldolization of 1 with the ketones.
