68935-48-8

Usage

Uses

4-Chloro-5-methoxy-1H-indole is used in the synthesis of melatonin analogs.

Upstream product

• 4920-79-0 2-chloro-4-nitroanisole 
• 3598-13-8 (4-chlorophenoxy)acetonitrile 

Relevant academic research and scientific papers

AROMATIC SIX-MEMBERED RING DERIVATIVE HAVING SUBSTITUENT AT META POSITION

PROBLEM TO BE SOLVED: To provide a compound having excellent inhibitory activity against a retinoic acid receptor-related orphan receptor γt. SOLUTION: Provided is a compound represented by a formula (I) or a pharmacologically acceptable salt thereof. [R1 is a C3 to C6 cycloalkyl group or a phenyl group which may be substituted with 1 to 4 substituents selected from a substituent group A; R2 is H, a C2 to C7 carboxyalkyl group, OH, or the like; a formula -U-T- represents a formula -CH2-CH2- or a formula -CH=CH-; R3 and R4 each independently represents H, a halogen, or a C1 to C6 alkyl group; Y represents a methylene group or O; R5 represents a phenyl group, a pyridyl group, or the like which may be substituted with 1 to 4 substituents selected from a substituent group B; Q1 is N or a formula =C(R6)-; Q2 is N or a formula =C(R7)-; R6 and R7 are each independently H, a halogen, or the like; the substituent group A includes C1 to C6 alkyl sulfonyl groups or the like; and the substituent group B includes a halogen, C1 to C6 alkyl groups, a hydroxyl group, or the like.] SELECTED DRAWING: None COPYRIGHT: (C)2016,JPOandINPIT

Tryptamine analogues, their synthesis and their use as 5-HT1 -like or 5-HT2 receptor agonists

The present invention relates to known and novel tryptamine analogues, processes and intermediates useful in their preparation, pharmaceutical compositions containing them and their use in therapy, in particular for the treatment and/or prophylaxis of dis

Synthesis and evaluation of the antiovulatory activity of a variety of melatonin analogues

A series of melatonin analogues was synthesized and examined for ovulation-blocking activity. Deviation from the 5-methoxy group or substitution of the 1 position prevented activity. Activity was not particularly sensitive to minor variations in the N-acyl group nor was it significantly altered by methylation of position 2 or the α-methylene; however, a pronounced enhancement resulted from halogenation of the 6 position.