68945-87-9Relevant academic research and scientific papers
Self-triggered click reaction in an Alzheimer's disease model:: In situ bifunctional drug synthesis catalyzed by neurotoxic copper accumulated in amyloid-β plaques
Du, Zhi,Yu, Dongqin,Du, Xiubo,Scott, Peter,Ren, Jinsong,Qu, Xiaogang
, p. 10343 - 10350 (2019)
Cu is one of the essential elements for life. Its dyshomeostasis has been demonstrated to be closely related to neurodegenerative disorders, such as Alzheimer's disease (AD), which is characterized by amyloid-β (Aβ) aggregation and Cu accumulation. It is
Antitumor benzothiazoles. Part 2. Formation of 2,2'-diaminobiphenyls from the decomposition of 2-(4-azidophenyl)benzazoles in trifluoromethanesulfonic acid
Stevens, Malcolm F. G.,Shi, Dong-Fang,Castro, Angeles
, p. 83 - 94 (2007/10/03)
Decomposition of 2-(2-azidophenyl)- and 2-(3-azidophenyl)-benzothiazoles in trifluoromethanesulfonic acid generates ?-carbocations.These reactive intermediates have been trapped by triflate anion with the nucleophile substituting para to the original azido group to yield triflate-substituted arylamines. 2-(4-Azidophenyl)-benzothiazoles and -benzoxazoles behave differently: triflate-substituted arylamines are accompanied by symmetrical or unsymmetrical benzazolyl-substituted 2,2'-diaminobiphenyls as major products.These biphenyls have been identified by their characteristic 1H and 13C NMR spectra. 2,2'-Diaminobiphenyls are formed by initial C-C coupling interactions between the ?-carbocations and undecomposed 2-(4-azidophenyl)benzazoles and not by benzidine-type rearrangements as originally proposed.Symmetrical 2,2'-diaminobiphenyls have been oxidized by (diacetoxyiodo) benzene to give novel benzazolyl-substituted benzocinnolines.
