68957-94-8

Basic information

• Product Name: Propylphosphonic anhydride
• Synonyms: T3P/Propanephosphonic acid cyclic anhydride;2,4,6-Tripropyl-1,3,5,2,4,6-trioxatriphosphinane 2,4,6-trioxide;1-Propylphosphonic acid cyclic anhydride, 50+% w/w soln. in dichloroMethane;1-Propylphosphonic acid cyclic anhydride, 50 wt.% solution in ethyl acetate;PPACA;Propylphosphonic anhydride solution technical, ~50% in DMF;1-Propylphosphonic anhydride solution, 50 wt. % in DMF;1-Propylphosphonic anhydride solution, 50 wt. % in ethyl acetate
• CAS NO: 68957-94-8
• Molecular Formula: C₉H₂₁O₆P₃
• Molecular Weight: 318.18
• EINECS: 422-210-5
• Mol File: 68957-94-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 65 °C
• Flash Point: 25 °F
• Appearance: Clear yellow to brownish/Solution
• Density: 1.069 g/mL at 25 °C
• Vapor Pressure: 7.51E-05mmHg at 25°C
• Refractive Index: n20/D 1.418
• Storage Temp.: Flammables area
• Solubility: Miscible with dioxane, terahydrofuran, dimethyl formamide, polar
• Water Solubility: 9.6g/L at 25℃
• Sensitive: Moisture Sensitive
• BRN: 5079255
• CAS DataBase Reference: Propylphosphonic anhydride(CAS DataBase Reference)
• NIST Chemistry Reference: Propylphosphonic anhydride(68957-94-8)
• EPA Substance Registry System: Propylphosphonic anhydride(68957-94-8)

Safety Data

• Hazard Codes: T,C,F
• Statements: 61-20/21-34-67-66-11
• Safety Statements: 53-26-36/37/39-45-33-16
• RIDADR: UN 2924 3/PG 3
• WGK Germany: 1
• F: 21
• TSCA: Yes
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 68957-94-8(Hazardous Substances Data)

Usage

Reaction

TP3 is an exceptional reagent for amide/peptide bond formation. The product is very easy to use and combines excellent?reaction selectivity, low epimerization, high yields and high product purities. Conversions of acids and amides to nitriles under mild conditions. Synthesis of urea and carbamate derivatives. Formation of thioacids from N-protected amino acids and peptides.

Uses

Different sources of media describe the Uses of 68957-94-8 differently. You can refer to the following data:
1. It is employed as an efficient promoter for the Lossen rearrangement to synthesis urea and carbamate derivatives.
2. Propylphosphonic anhydride may be used in the following studies:As coupling agent for the synthesis of bispyridine-based ligands, which are used as bridging linkers in multinuclear platinum anticancer drugs.Microwave-assissted Fischer indolization of arylhydrazines.As acid activating agent for the direct synthesis of acid azides from carboxylic acids.One-pot synthesis of coumarins.Microwave-mediated synthesis of carbocyclic and heterocyclic fused quinolones.One-pot synthesis of 1,2,4-oxadiazoles, 1,3,4-oxadiazoles, and 1,3,4-thiadiazoles from carboxylic acids.Activation of the carboxyl group for hydroxyamidation and peptide coupling and in the one-pot conversion of carboxylic acids into hydroxamic acids.

General Description

Propylphosphonic anhydride (T3P) is a reactive n-propyl phosphonic acid cyclic anhydride. It is a mild and low toxic coupling agent used in peptide synthesis. T3P also acts as a promoter and water scavenger in the Friedl?nder annulation reaction. It participates in the conversion of carboxylic acids and amides into nitriles, formation of Weinreb amides, ester synthesis, dehydrations, oxidation of alcohols, isonitrile synthesis, synthesis of alkenes from alcohols and C-C coupling reactions. T3P delivers outstanding advantages over traditional reagents, such as broad functional group tolerance, low epimerization, and water-soluble by-products and hence gives high purity and yield of the product.

Flammability and Explosibility

Notclassified

InChI:InChI=1/C9H21O6P3/c1-4-7-16(10)13-17(11,8-5-2)15-18(12,14-16)9-6-3/h4-9H2,1-3H3

Synthetic route

propylphosphonic dichloride (4708-04-7) → 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide (68957-94-8)

Conditions	Yield
With water 1) 1 h, 2) 3 h, 80 deg C, 17 Torr, 3) 3 h, 80 deg C, 5 Torr;	100%

propanephosphonic acid dimethyl ester (18755-43-6) → 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide (68957-94-8)

Conditions	Yield
With acetic anhydride; 1-ethyl-3-methylimidazolium tetrafluoroborate at 45℃; for 4.5h; Temperature; Reflux;	95.14%

propylphosphonic dichloride (4708-04-7) + propylphosphonic anhydride (71760-04-8) → 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide (68957-94-8)

Conditions	Yield
In toluene at 90℃; for 8h; Concentration; Temperature; Inert atmosphere;	82.93%

propylphosphonic acid (4672-38-2) → 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide (68957-94-8)

Conditions	Yield
Stage #1: propylphosphonic acid With acetic anhydride for 2h; Heating / reflux; Stage #2: at 350℃; under 0.0750075 - 75.0075 Torr;	80%
Stage #1: propylphosphonic acid With acetic anhydride for 24h; Reflux; Inert atmosphere; Stage #2: at 300℃; under 0.225023 Torr; Inert atmosphere;	72%
With thionyl chloride In toluene at 80℃; for 3.25h; Product distribution / selectivity; Reflux;

propylphosphonic dichloride (4708-04-7) + diethyl propylphosphonate (18812-51-6) → 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide (68957-94-8)

Conditions	Yield
at 115 - 260℃; for 3h; Temperature;	69%

4-(6-methyl-pyridazin-3-yl)-benzylamine (389602-89-5) + 4-(4'-trifluoromethyl-biphenyl-2-carbonylamino)-1-methyl-imidazol-2-carboxylic acid (486437-06-3) + 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide (68957-94-8) → N-[4-(6-methyl-pyridazin-3-yl)-phenylmethyl]-4-(4'-trifluoro-methylbiphenyl-2-carbonylamino)-1-methyl-imidazole-2-carboxylic acid amide (486434-85-9)

Conditions	Yield
With 4-methyl-morpholine In dichloromethane	96%
With 4-methyl-morpholine In dichloromethane	96%

3-(biphenyl-2-carbonylamino)-benzoic acid + [4-(1H-imidazol-2-yl)phenyl]methanamine (326409-72-7) + 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide (68957-94-8) → N-[4-(1H-imidazol-2-yl)-phenylmethyl]-3-(biphenyl-2-carbonylamino)-benzoic acid amide-hydrochloride (389601-32-5)

Conditions	Yield
With 4-methyl-morpholine In dichloromethane	96%

3-({[4'-(trifluoromethyl)-1,1'-biphenyl-2-yl]carbonyl}amino)benzoic acid (389602-62-4) + 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide (68957-94-8) + benzyl-methyl-amine (103-67-3) → N-phenylmethyl-N-methyl-3-(4'-trifluoromethylbiphenyl-2-carbonylamino)-benzoic acid amide (389601-29-0)

Conditions	Yield
With 4-methyl-morpholine In dichloromethane	95%

6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxylic acid + 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide (68957-94-8) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → tert-butyl 4-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]piperazine-1-carboxylate

Conditions	Yield
With triethylamine In tetrahydrofuran; diethyl ether; water; ethyl acetate	95%

4-(4'-trifluoromethyl-biphenyl-2-carbonylamino)-1-methyl-imidazol-2-carboxylic acid (486437-06-3) + 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide (68957-94-8) + 4-(pyridin-4-yl)-benzylamine (486437-10-9) → N-[4-(pyridin-4-yl)-phenylmethyl]-4-(4'-trifluoromethylbiphenyl-2-carbonylamino)-1-methyl-imidazole-2-carboxylic acid amide (486434-82-6)

Conditions	Yield
With 4-methyl-morpholine In dichloromethane	94%

(1H-benzo[d]imidazol-5-yl)methanamine + 3-({[4'-(trifluoromethyl)-1,1'-biphenyl-2-yl]carbonyl}amino)benzoic acid (389602-62-4) + 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide (68957-94-8) → N-(1H-Benzimidazol-5-ylmethyl)-3-(4'-trifluoromethylbiphenyl-2-carbonylamino)-benzoic acid amide (389601-65-4)

Conditions	Yield
With 4-methyl-morpholine In dichloromethane	93%

3-({[4'-(trifluoromethyl)-1,1'-biphenyl-2-yl]carbonyl}amino)benzoic acid (389602-62-4) + 3-methyl-4-(phenylcarbonylamino)-benzylamine (389602-74-8) + 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide (68957-94-8) → N-[3-methyl-4-(phenylcarbonylamino)-phenylmethyl]-3-(4'-trifluoromethylbiphenyl-2-carbonylamino)-benzoic acid amide (389601-72-3)

Conditions	Yield
With 4-methyl-morpholine In dichloromethane	89%

4-(4'-trifluoromethyl-biphenyl-2-carbonylamino)-1-methyl-imidazol-2-carboxylic acid (486437-06-3) + (4'-chloro-[1,1'-biphenyl]-4-yl)methanamine (15996-82-4) + 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide (68957-94-8) → N-(4'-Chlorobiphenyl-4-yl)methyl-4-(4'-trifluoromethylbiphenyl-2-carbonylamino)-1-methyl-imidazol-2-carboxylic acid amide (486434-80-4)

Conditions	Yield
With 4-methyl-morpholine In dichloromethane	88%
With 4-methyl-morpholine In dichloromethane	88%

4-(4'-trifluoromethyl-biphenyl-2-carbonylamino)-1-methyl-imidazol-2-carboxylic acid (486437-06-3) + 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide (68957-94-8) + [4-(1,2,3-thiadiazol-4-yl)phenyl]methanamine → N-[4-([1,2,3]-thiadiazol-4-yl)-phenylmethyl]-4-(4'-trifluoro-methylbiphenyl-2-carbonylamino)-1-methyl-imidazole-2-carboxylic acid amide (486434-84-8)

Conditions	Yield
With 4-methyl-morpholine In dichloromethane	88%
With 4-methyl-morpholine In dichloromethane	88%

(4-(piperidin-1-yl)phenyl)methanamine (214759-73-6) + 4-(4'-trifluoromethyl-biphenyl-2-carbonylamino)-1-methyl-imidazol-2-carboxylic acid (486437-06-3) + 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide (68957-94-8) → N-[4-(piperidino)-phenylmethyl]-4-(4'-trifluoromethyl-biphenyl-2-carbonylamino)-1-methyl-imidazol-2-carboxylic acid amide (486434-74-6)

Conditions	Yield
With 4-methyl-morpholine In dichloromethane	88%

3-(biphenyl-2-carbonylamino)-benzoic acid + N-(4-phenyl)benzylamine (712-76-5) + 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide (68957-94-8) → N-(biphenyl-4-methyl)-3-(biphenyl-2-carbonylamino)-benzoic acid amide

Conditions	Yield
With 4-methyl-morpholine In dichloromethane	88%

4-methyl-morpholine (109-02-4) + 4-(3,4-dihydro-2H-quinolin-1-yl)-benzylamine (486436-88-8) + 4-(4'-trifluoromethyl-biphenyl-2-carbonylamino)-1-methyl-imidazol-2-carboxylic acid (486437-06-3) + 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide (68957-94-8) → N-[4-(3,4-dihydro-2H-quinolin-1-yl)-phenylmethyl]-4-(4'-trifluoromethylbiphenyl-2-carbonylamino)-1-methyl-imidazol-2-carboxylic acid amide (486434-76-8)

Conditions	Yield
In dichloromethane	85%

4-(3,4-dihydro-2H-quinolin-1-yl)-benzylamine (486436-88-8) + 4-(4'-trifluoromethyl-biphenyl-2-carbonylamino)-1-methyl-imidazol-2-carboxylic acid (486437-06-3) + 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide (68957-94-8) → N-[4-(3,4-dihydro-2H-quinolin-1-yl)-phenylmethyl]-4-(4'-trifluoromethylbiphenyl-2-carbonylamino)-1-methyl-imidazol-2-carboxylic acid amide (486434-76-8)

Conditions	Yield
With 4-methyl-morpholine In dichloromethane	85%

3-({[4'-(trifluoromethyl)-1,1'-biphenyl-2-yl]carbonyl}amino)benzoic acid (389602-62-4) + 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide (68957-94-8) + para-methylbenzylamine (104-84-7) → N-(4-methyl-phenylmethyl)-3-(4'-trifluoromethylbiphenyl-2-carbonylamino)-benzoic acid amide (389601-59-6)

Conditions	Yield
With 4-methyl-morpholine In dichloromethane	82%

3-({[4'-(trifluoromethyl)-1,1'-biphenyl-2-yl]carbonyl}amino)benzoic acid (389602-62-4) + 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide (68957-94-8) → N-(pyridine-3-yl-methyl)-3-(4'-trifluoromethylbiphenyl-2-carbonylamino)-benzoic acid amide (389601-12-1)

Conditions	Yield
With 4-methyl-morpholine In dichloromethane	81%

3-({[4'-(trifluoromethyl)-1,1'-biphenyl-2-yl]carbonyl}amino)benzoic acid (389602-62-4) + glycine ethyl ester hydrochloride (623-33-6) + 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide (68957-94-8) → N-ethoxycarbonylmethyl-3-(4'-trifluoromethylbiphenyl-2-carbonylamino)-benzoic acid amide (389601-27-8)

Conditions	Yield
With 4-methyl-morpholine In dichloromethane	79%

3-({[4'-(trifluoromethyl)-1,1'-biphenyl-2-yl]carbonyl}amino)benzoic acid (389602-62-4) + 4-aminomethyl-benzenesulfonic acid anilide (6325-23-1) + 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide (68957-94-8) → N-(4-phenylaminosulphonyl-phenylmethyl)-3-(4'-trifluoromethylbiphenyl-2-carbonylamino)-benzoic acid amide (389601-47-2)

Conditions	Yield
With 4-methyl-morpholine In dichloromethane	73%

4-methyl-morpholine (109-02-4) + 3-(4-(trifluoromethyl)phenyl)prop-2-yn-1-amine (486437-19-8) + 4-(4'-trifluoromethyl-biphenyl-2-carbonylamino)-1-methyl-imidazol-2-carboxylic acid (486437-06-3) + 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide (68957-94-8) → N-[3-(4-Trifluoromethylphenyl)-prop-2-ynyl]-4-(4'-trifluoromethylbiphenyl-2-carbonylamino)-1-methyl-imidazole-2-carboxylic acid amide (486434-91-7)

Conditions	Yield
In dichloromethane	71%

3-(4-(trifluoromethyl)phenyl)prop-2-yn-1-amine (486437-19-8) + 4-(4'-trifluoromethyl-biphenyl-2-carbonylamino)-1-methyl-imidazol-2-carboxylic acid (486437-06-3) + 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide (68957-94-8) → N-[3-(4-Trifluoromethylphenyl)-prop-2-ynyl]-4-(4'-trifluoromethylbiphenyl-2-carbonylamino)-1-methyl-imidazole-2-carboxylic acid amide (486434-91-7)

Conditions	Yield
With 4-methyl-morpholine In dichloromethane	71%

1-(2-amino-4-bromophenyl)-4-(2-aminophenyl)-2-(4-bromophenyl)butane-1,4-dione + 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide (68957-94-8) → 11-bromo-7-(4-bromophenyl)-7,13-dihydro-8H-benzo[6,7]azepino[3,2-c]quinolin-8-one

Conditions	Yield
In N,N-dimethyl-formamide at 80℃; for 24h;	69%

3-bromobenzene-1,2-diamine (1575-36-6) + 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide (68957-94-8) + N-(Benzyloxycarbonyl)glycine (1138-80-3) → benzyl [2-(2-amino-3-bromoanilino)-2-oxoethyl]carbamate

Conditions	Yield
Stage #1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-(Benzyloxycarbonyl)glycine With N-ethyl-N,N-diisopropylamine In dichloromethane; ethyl acetate at 0 - 20℃; for 0.5h; Stage #2: 3-bromobenzene-1,2-diamine In dichloromethane; ethyl acetate at 20℃; for 12h;	69%

(4S,6S)-4-(5-amino-3-chloro-2-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine (1624606-76-3) + 5-cyano-pyridine-2-carboxylic acid (53234-55-2) + 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide (68957-94-8) → N-(3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-5-chloro-4-fluorophenyl)-5-cyanopicolinamide (1624605-05-5)

Conditions	Yield
In N,N-dimethyl-formamide	68.3%

1-(2-amino-4-bromophenyl)-4-(2-aminophenyl)-2-(4-(trifluoromethyl)phenyl)butane-1,4-dione + 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide (68957-94-8) → 11-bromo-7-(4-(trifluoromethyl)phenyl)-7,13-dihydro-8H-benzo[6,7]azepino[3,2-c]quinolin-8-one

Conditions	Yield
In N,N-dimethyl-formamide at 80℃; for 24h;	68%

4-(1,4-dioxa-spiro[4.5]dec-8-yl)-benzylamine (178163-63-8) + 4-(4'-trifluoromethyl-biphenyl-2-carbonylamino)-1-methyl-imidazol-2-carboxylic acid (486437-06-3) + 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide (68957-94-8) → N-[4-(1,4-dioxa-spiro[4.5]dec-8-yl)-phenylmethyl]-4-(4'-trifluoromethylbiphenyl-2-carbonylamino)-1-methyl-imidazole-2-carboxylic acid amide (486434-93-9)

Conditions	Yield
With 4-methyl-morpholine In dichloromethane	67%
With 4-methyl-morpholine In dichloromethane	67%

1-(2-amino-4-bromophenyl)-4-(2-aminophenyl)-2-phenylbutane-1,4-dione + 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide (68957-94-8) → 11-bromo-7-phenyl-7,13-dihydro-8H-benzo[6,7]azepino[3,2-c]quinolin-8-one

Conditions	Yield
In N,N-dimethyl-formamide at 80℃; for 24h;	66%

Upstream product

• 4672-38-2 propylphosphonic acid 
• 4708-04-7 propylphosphonic dichloride 
• 18812-51-6 diethyl propylphosphonate 
• 71760-04-8 propylphosphonic anhydride 
• 18755-43-6 propanephosphonic acid dimethyl ester 

Downstream Products

• 486434-73-5 N-(biphenyl-4-yl)methyl-4-(4'-trifluoromethylbiphenyl-2-carbonylamino)-1-methyl-imidazol-2-carboxylic acid amide 
• 486434-84-8 N-[4-([1,2,3]-thiadiazol-4-yl)-phenylmethyl]-4-(4'-trifluoro-methylbiphenyl-2-carbonylamino)-1-methyl-imidazole-2-carboxylic acid amide 
• 389601-59-6 N-(4-methyl-phenylmethyl)-3-(4'-trifluoromethylbiphenyl-2-carbonylamino)-benzoic acid amide 
• 389601-27-8 N-ethoxycarbonylmethyl-3-(4'-trifluoromethylbiphenyl-2-carbonylamino)-benzoic acid amide 
• 389601-46-1 N-(4-[1,2,3]-thiadiazol-4-yl-phenylmethyl)-3-(4'-trifluoro-methylbiphenyl-2-carbonylamino)-benzoic acid amide 
• 389602-01-1 N-[4-(pyrimidin-4-yl-carbonylamino)-phenylmethyl]-3-(4'-trifluoromethylbiphenyl-2-carbonylamino)-benzoic acid amide 
• 1363334-43-3 C₂₆H₄₂N₃O₆⁽¹⁺⁾*Cl^(1-) 
• 1363334-40-0 C₂₂H₃₄N₃O₄⁽¹⁺⁾*Cl^(1-) 
• 486434-91-7 N-[3-(4-Trifluoromethylphenyl)-prop-2-ynyl]-4-(4'-trifluoromethylbiphenyl-2-carbonylamino)-1-methyl-imidazole-2-carboxylic acid amide 
• 486434-76-8 N-[4-(3,4-dihydro-2H-quinolin-1-yl)-phenylmethyl]-4-(4'-trifluoromethylbiphenyl-2-carbonylamino)-1-methyl-imidazol-2-carboxylic acid amide 
• 486436-22-0 N-[3-(4-isopropylphenyl)-prop-2-ynyl]-4-(4'-trifluoromethyl-biphenyl-2-carbonylamino)-1-methyl-imidazole-2-carboxylic acid amide 
• 486434-95-1 N-[3-(4-tert.butylphenyl)-prop-2-ynyl]-4-(4'-trifluoromethyl-biphenyl-2-carbonylamino)-1-methyl-imidazole-2-carboxylic acid amide 
• 486434-93-9 N-[4-(1,4-dioxa-spiro[4.5]dec-8-yl)-phenylmethyl]-4-(4'-trifluoromethylbiphenyl-2-carbonylamino)-1-methyl-imidazole-2-carboxylic acid amide 
• 486434-74-6 N-[4-(piperidino)-phenylmethyl]-4-(4'-trifluoromethyl-biphenyl-2-carbonylamino)-1-methyl-imidazol-2-carboxylic acid amide 

Relevant articles and documents

Synthesis method of 1-propyl phosphoric acid cyclic anhydride

The invention provides a 1-propyl phosphoric acid cyclic anhydride synthesis method, which comprises: S1, carrying out a chlorination reaction on 1-propyl diethyl phosphate and a chlorination reagentto obtain a 1-propyl phosphorus dichloride intermediate; and S2, heating the 1-propyl phosphorus dichloride intermediate and 1-propyl diethyl phosphate to 100-300 DEG C, and carrying out a cyclizationreaction to obtain the 1-propyl phosphoric acid cyclic anhydride. The embodiment of the invention discloses a synthetic method of 1-propyl phosphoric acid cyclic anhydride. According to the method, diethyl 1-propylphosphate is used as a starting raw material, and chlorination is performed under the action of dichloromethane and thionyl chloride to prepare the 1-propylphosphorus dichloride intermediate, so that the product can be obtained by adopting simple, easily available and cheap raw materials through a two-step reaction, the production cost is low, and the method is suitable for industrial production.

An improved 1-propyl phosphonic acid of anhydrides and nitriles preparation method (by machine translation)

The invention relates to an improved preparation method of 1-propylphosphoric cyclic anhydride, which comprises the following steps: 1) adding dimethylpropyl phosphate into an ionic liquid solvent while controlling the temperature at 0-80 DEG C, adding acetic anhydride at the same technical temperature within 1-3 hours, and heating to react under reflux for 1-8 hours to obtain a reaction solution, wherein the mol ratio of the ionic liquid solvent to the dimethylpropyl phosphate to the acetic anhydride is (10-15):(2.0-2.8):1; 2) after finishing refluxing, distilling the reaction solution at 80-140 DEG C under normal pressure to remove low-boiling-point substances; and 3) carrying out vacuum distillation on the distilled reaction solution at 235-260 DEG C to obtain the 1-propylphosphoric cyclic anhydride. The product prepared by the method is a colorless syrupy thick liquid; the yield is greater than or equal to 93%, and the content is 98-99.5%; and compared with the prior art, the yield and technique are greatly enhanced.

PROCESS

The present invention relates to a process for recovering a phosphonic acid. The present invention also relates to the conversion of a phosphonic acid to a phosphonic acid anhydride.