68997-50-2Relevant articles and documents
Discovery of a sulfamate-based steroid sulfatase inhibitor with intrinsic selective estrogen receptor modulator properties
Ouellet, Charles,Maltais, René,Ouellet, étienne,Barbeau, Xavier,Lagüe, Patrick,Poirier, Donald
, p. 169 - 182 (2016)
Steroid sulfatase (STS), the enzyme which converts inactive sulfated steroid precursors into active hormones, is a promising therapeutic target for the treatment of estrogen-sensitive breast cancer. We report herein the synthesis and in vitro study of dua
COMPOUNDS FOR THE TREATMENT OF HORMONE-DEPENDENT DISEASES
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Paragraph 0046; 0064; 0065; 0066, (2015/03/13)
Provided are compounds of general formula A and A', wherein X1 and X2 are each C, CH or N; R3 and R4 are each H, optionally substituted C1-C30 saturated or unsaturated chemical group, or to