69004-04-2 Usage
Uses
Used in Veterinary Medicine:
Ponazuril is used as an antiprotozoal agent for the treatment of Equine Protozoal Myeloencephalitis (EPM) in horses. It effectively targets and eliminates the protozoal parasite responsible for EPM, leading to improved health and reduced neurological symptoms in affected horses.
Used in Human Medicine (Toxoplasmosis Treatment):
Ponazuril is also used as an antiprotozoal agent for the treatment of toxoplasmosis in humans. It is particularly effective in preventing infection with Toxoplasma gondii tachyzoites in mouse models of fatal toxoplasmosis when administered at appropriate doses. Additionally, it has been shown to reduce the number of infected individuals when administered following the onset of infection, highlighting its potential utility in both prophylactic and therapeutic settings.
Veterinary Drugs and Treatments
Ponazuril is indicated for the treatment of equine protozoal myeloencephalitis
(EPM) caused by Sarcocystis neurona.
Ponazuril could potentially be useful in treating Neospora caninum
and Toxoplasma infections in dogs or cats.
Check Digit Verification of cas no
The CAS Registry Mumber 69004-04-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,9,0,0 and 4 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 69004-04:
(7*6)+(6*9)+(5*0)+(4*0)+(3*4)+(2*0)+(1*4)=112
112 % 10 = 2
So 69004-04-2 is a valid CAS Registry Number.
InChI:InChI=1/C18H14F3N3O6S/c1-10-9-11(24-16(26)22-15(25)23(2)17(24)27)3-8-14(10)30-12-4-6-13(7-5-12)31(28,29)18(19,20)21/h3-9H,1-2H3,(H,22,25,26)
69004-04-2Relevant academic research and scientific papers
Preparation of ponazuril and toltrazuril
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Paragraph 0017; 0019, (2020/06/09)
The invention relates to preparation of ponazuril and toltrazuril, in particular to a reaction of 1-(4-halogenated-3-methylphenyl)-3-methyl-1,3,5-triazine-2,4,6-trione and p-substituted phenol in thepresence of a copper catalyst/alkali/additive/solvent. The process is simple to operate and has an industrial large-scale production prospect.
