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69004-04-2

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69004-04-2 Usage

Description

Toltrazuril sulfone is an active metabolite of the coccidiostat toltrazuril . Toltrazuril sulfone is formed from toltrazuril via the intermediate metabolite toltrazuril sulfoxide by cytochrome P450 (CYP) enzymes, including CYP3A. It inhibits T. gondii tachyzoite production in African green monkey kidney cells when used at concentrations of 0.1, 1, and 5 μg/ml. Toltrazuril sulfone completely prevents infection with T. gondii tachyzoites in a mouse model of fatal toxoplasmosis when administered at doses of 10 or 20 mg/kg one day prior to, and daily for 10 days following, infection. It also reduces the number of infected mice in the same model when administered at a dose of 10 mg/kg for 11 days starting six days following infection. Formulations containing toltrazuril sulfone have been used in the treatment of equine protozoal myeloencephalitis (EPM) in horses.

Uses

Toltrazuril sulfone is antiprotazoal, used to treat Equine Protozoal Myeloencephalitis (EPM).

Veterinary Drugs and Treatments

Ponazuril is indicated for the treatment of equine protozoal myeloencephalitis (EPM) caused by Sarcocystis neurona. Ponazuril could potentially be useful in treating Neospora caninum and Toxoplasma infections in dogs or cats.

Check Digit Verification of cas no

The CAS Registry Mumber 69004-04-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,9,0,0 and 4 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 69004-04:
(7*6)+(6*9)+(5*0)+(4*0)+(3*4)+(2*0)+(1*4)=112
112 % 10 = 2
So 69004-04-2 is a valid CAS Registry Number.
InChI:InChI=1/C18H14F3N3O6S/c1-10-9-11(24-16(26)22-15(25)23(2)17(24)27)3-8-14(10)30-12-4-6-13(7-5-12)31(28,29)18(19,20)21/h3-9H,1-2H3,(H,22,25,26)

69004-04-2 Well-known Company Product Price

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  • Sigma-Aldrich

  • (33816)  Toltrazurilsulfone  VETRANAL, analytical standard

  • 69004-04-2

  • 33816-10MG

  • 2,069.73CNY

  • Detail

69004-04-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-methyl-3-[3-methyl-4-[4-(trifluoromethylsulfonyl)phenoxy]phenyl]-1,3,5-triazinane-2,4,6-trione

1.2 Other means of identification

Product number -
Other names Toltrazuril sulfone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:69004-04-2 SDS

69004-04-2Downstream Products

69004-04-2Relevant articles and documents

Preparation of ponazuril and toltrazuril

-

Paragraph 0017; 0019, (2020/06/09)

The invention relates to preparation of ponazuril and toltrazuril, in particular to a reaction of 1-(4-halogenated-3-methylphenyl)-3-methyl-1,3,5-triazine-2,4,6-trione and p-substituted phenol in thepresence of a copper catalyst/alkali/additive/solvent. The process is simple to operate and has an industrial large-scale production prospect.

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