69010-17-9

Basic information

• Product Name: 1,2-Cyclopropanedicarbonyl dichloride, cis- (9CI)
• Synonyms: 1,2-Cyclopropanedicarbonyl dichloride, cis- (9CI)
• CAS NO: 69010-17-9
• Molecular Formula: C₅H₄Cl₂O₂
• Molecular Weight: 166.99006
• Product Categories: ACIDHALIDE
• Mol File: 69010-17-9.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,2-Cyclopropanedicarbonyl dichloride, cis- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Cyclopropanedicarbonyl dichloride, cis- (9CI)(69010-17-9)
• EPA Substance Registry System: 1,2-Cyclopropanedicarbonyl dichloride, cis- (9CI)(69010-17-9)

Safety Data

• Hazardous Substances Data: 69010-17-9(Hazardous Substances Data)

Usage

Bicyclic compound

Yes

Contains carbonyl groups

2

Contains chlorine atoms

2

Attached to a cyclopropane ring

Yes

Potential use

Reagent in organic synthesis

Reacts with

Various nucleophiles

Forms

Wide range of derivatives

Safety concerns

Potential irritant to skin, eyes, and respiratory system

Handling precautions

Use proper safety precautions

Storage precautions

Handle with care due to potential hazardous nature

Upstream product

• 3999-55-1 diethyl trans-cyclopropane-1,2-dicarboxylate 
• 58616-95-8 trans-1,2-cyclopropanedicarboxylic acid 
• 826-34-6 dimethyl cis-cyclopropane-1,2-dicarboxylate 

Downstream Products

• 96149-00-7 (1S,2S)-cyclopropane-1,2-dicarboxylic acid bis-(1R,2S,5R)-(5-isopropyl-2-methyl-cyclohexyl) ester 
• 53187-82-9 (trans-cyclopropane-1,2-diyl)dimethanol 
• 35974-53-9 (+/-)-trans-2-dimethylcarbamoyl-cyclopropanecarboxylic acid 
• 3187-76-6 (trans)-cyclopropane-1,2-diamine dihydrochloride 

Relevant articles and documents

ALKYLBORONIC ACIDS AS ARGINASE INHIBITORS

Provided are alkylboronic acids as arginase inhibitors represented by formula (I), or a pharmaceutically acceptable salt, stereoisomer, tautomer, or prodrug thereof and a pharmaceutical composition comprising said compounds.

CYCLOPROPYL-CONTAINING POLYAMINE ANALOGS AS DISEASE THERAPIES

This disclosure relates to specific polyamine analogs and methods of treating cancer using polyamine analogs. The polyamine analogs have cyclopropyl groups in their internal segments.

Photodecarbonylation of chiral cyclobutanones

Triplet photosensitized irradiation of 2(S),3(R)-bis[(benzoyloxy)methyl]cyclobutanone gave optically pure (-)E-1(S),2(S)-bis(benzoyloxymethyl)cyclopropaneas a major product in the nonpolar fraction along with its stereoisomer and cycloelimination products. The absolute stereochemistry of the chiral cyclopropane was established by independent synthesis and X-ray crystal structure determination of a synthetic precursor. The distribution of decarbonylation and cycloelimination products was inversely dependent on the concentration of the substrate. Irradiation of the same ketone in tetrahydrofuran or benzene gave mostly cycloelimination products. Addition of Michler's ketone increased the ratio of photodecarbonylation, suggesting a triplet state pathway for this process. This was corroborated by the addition of dicyanoethylene, which showed significant quenching of photodecarbonylation. Irradiation of 2(S)-[(benzoyloxy)methyl]cyclobutane in acetone gave the corresponding cyclopropane as the principal product.