690213-76-4

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 90-02-8 salicylaldehyde 
• 3949-36-8 3-acetylcoumarin 
• 51791-26-5 3-(4-fluoro-phenyl)-propenal 

Downstream Products

• 1323381-34-5 3-(4-fluorostyryl)-1-(phenylimino)cyclopenta[c]chromen-4(1H)-one 
• 1323381-28-7 3-[4-(4-fluorophenyl)-2-(phenylimino)-2H-pyran-6-yl]-2Hchromen-2-one 
• 1323381-32-3 3-{[2-(4-fluorophenyl)-4-(phenylimino)cyclobut-2-enecarbon]-1-yl}-2H-chromen-2-one 
• 1323381-50-5 3-[2-(4-fluorophenyl)ethenyl]cyclopenta[c]chromene-1,4-dione 
• 1323381-44-7 3-[4-(4-fluorophenyl)-2-oxo-3-(triphenyl-λ5-phosphanylidene)-3,4-dihydro-2H-pyran-6-yl]-2Hchromen-2-one 
• 1323381-48-1 3-{[2-(4-fluorophenyl)-4-oxo-3-(triphenyl-λ5-phosphanylidene)cyclobutyl]carbonyl}-2H-chromen-2-one 
• 929297-87-0 5-(4-fluoro-phenyl)-7-(2-oxo-2H-chromen-3-yl)-5H-thiazolo[3,2-a]pyrimidin-3-one 
• 324-27-6 2-(4-fluorophenyl)-1H-benzoimidazole 
• 1032-97-9 3-(1H-benzimidazol-2-yl)coumarin 
• 929298-04-4 3-[4-(4-fluoro-phenyl)-2,3-dihydro-1H-benzo[b][1,4]diazepin-2-yl]-chromen-2-one 

Relevant academic research and scientific papers

Cesium-Doped Tungstophosphoric Acid: An Efficient, Recyclable Catalyst for the Synthesis of 3-(3-(Substituted aryl/heteroaryl)acryloyl)-2H-chromen-2-one Derivatives in Water

The synthesis of a series of 3-(3-(substituted aryl/heteroaryl)acryloyl)-2H-chromen-2-one derivatives (3a-h) was achieved using cesium-doped tungstophosphoric acid (CsPW) as a catalysis in water. The recyclable catalyst Cs PW was characterized by Fourier

Novel coumarin-pyrazoline hybrids: synthesis, cytotoxicity evaluation and molecular dynamics study

A novel series of coumarin-pyrazoline hybrids3a-f,4a-cand5a-chave been synthesized and tested for their antiproliferative activity against the breast cancer cell line MCF-7. The most active compounds3d,3e,3f,5aand5cwere also evaluated for their ability to

Synthesis and biological evaluation of new coumarin derivatives as cytotoxic agents

New coumarin derivatives 9a–f, 10a–e, and 11a–f were synthesized and evaluated for their cytotoxic activity against a human breast cancer cell line (MCF-7). All compounds exhibited good activity in the nanomolar range, using doxorubicin and erlotinib as positive controls. The most active compound 9d with IC50 of 21 nM was tested against the HCT-116, HepG-2, A549, and SGC-7901 cell lines, with IC50 values of 0.021, 0.170, 0.028, and 0.11 μM, respectively. Compound 9d was further investigated for its ability to suppress the expression of epidermal growth factor receptor (EGFR). Compound 9d decreased the concentration of EGFR by 87%, using erlotinib as a positive control. A docking study revealed similar or higher scores than for erlotinib and similar binding poses providing interactions with the hinge region of the tyrosine kinase (TK). Besides the effect on expression, this in silico investigation predicts the possibility of direct binding between the new coumarin derivatives and the EGFR TK. Moreover, computational calculation for ADME properties for the most active compounds 9d, 9e, 10c, and 11c revealed the expected high gastrointestinal tract absorption, moderate water solubility with no central nervous system toxicity, and druglikeness.

ZnS nanoparticles immobilized on graphitic carbon nitride as a recyclable and environmentally friendly catalyst for synthesis of 3-cinnamoyl coumarins

Abstract: Zinc oxide nanoparticles immobilized on a graphitic carbon nitride (ZnS NPs/g-C3N4) nanocomposite were applied as an organometallic recyclable catalyst in the synthesis of coumarin–chalcone hybrids through the Claisen–Schmi

Synthesis and optical properties research of some novel trichromophore compounds containing coumarin, pyrazoline and naphthalimide groups

A series of novel trichromophore compounds containing coumarin, pyrazoline and naphthalimide groups were synthesized and their properties were elucidated using absorption and fluorescence. In chloroform solution, their maximal absorption bands and the max

Synthesis and florescent properties of 5-aryl-3-(3-coumarinyl)-1-benzothiazolyl-2-pyrazolines

A series of novel 5-Aryl-3-(3-coumarinyl)-1-benzothiazolyl-2-pyrazolines have been synthesized by the reaction of 3-coumarinyl chalcones with 2-hydrazinobenzothiazole in hot ethanol. And the structures of these new compounds have been characterized by 1HNMR, MS and elemental analysis. The fluorescence spectra of these compounds were also measured. All the compounds showed up strong green light emissions (λem: 557-570nm). The results showed that the absorption maxima of the compound vary from 415 to 420nm depending on the group bonded to pyrazolines rings.

Bismuth triflate: A highly efficient catalyst for the synthesis of bio-active coumarin compounds via one-pot multi-component reaction

A series of coumarin-chalcone hybrid compounds and coumarins linked to pyrazoline was synthesized in good yield and short time using a simple and efficient method. This method involved the one-pot reaction of salicylaldehyde, an α-ketoester and an aromatic aldehyde (in the case of the coumarin-chalcone derivatives) in addition to hydrazine hydrate (in the case of the pyrazolyl coumarins) in the presence of a catalytic amount of bismuth triflate [Bi(OTf)3, 5 mol%]. The synthesized compounds showed scavenging activity towards the free radical 2,2-diphenyl-1-picrylhydrazyl. All compounds were characterized using IR, 1H NMR and 13C NMR spectroscopy.

Novel 2H-chromen derivatives: Design, synthesis and anticancer activity

A series of novel dihydropyrazole derivatives linked with 2H-chromen were designed and synthesized. All of the compounds have been screened for their antiproliferative activity against MGC-803, Bcap-37, SGC-7901 and HepG 2 cell lines in vitro. The results revealed that compounds 4a and 10a exhibited strong inhibitory activity against HepG2 cell and manifested obvious un-toxic effect on GES-1 and L-02 cell lines. Some title compounds were tested against telomerase, compound 10a showed the most potent inhibitory activity with IC50 value at 0.98 ± 0.11 μM, it could fit well into the active site of TERT. The further molecular mechanism of antiproliferation was explored, the data suggested that compound 10a could inhibit hTERT expression and Wnt/β-catenin signaling.

Novel 3-(1-(2-(2,7a-dihydrobenzo[d]thiazol-2-ylthio)acetyl)-5-substituted- phenyl-4,5-dihydro-1H-pyrazol-3-yl)-Coumarins: Synthesis and anticancer activity

Seven novel 3-(1-(2-(2,7a-dihydrobenzo[d]thiazol-2-ylthio)acetyl)-5- substituted-phenyl-4,5-dihydro-1H-pyrazol-3-yl)-2H-chromen-2-one derivatives were synthesized and characterized by 1H NMR and 13 C NMR. All of the compounds have be

Synthesis and biological evaluation of a novel series of 1,3-dicoumarinyl-5-aryl-2-pyrazolines

In the present paper novel 1,3,5-trisubstituted 2-pyrazolines (4a-q) were synthesized via condensation of different substituted 3-cinnamoyl-2-oxo-2H- chromenes (2a-q) with 2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetohydrazide (3). Chalcones were prepared vi