690223-69-9

Upstream product

• 168899-58-9 3-acetoxy-2-methylbenzoic acid 
• 690223-68-8 (-)-(3S,4aS,8aS,2'R,3'R)-[3'-amino-2'-hydroxy-3'-(thiophen-2-yl)-propyl]-decahydro-isoquinoline-3-carboxylic acid tert-butylamide 
• 13979-15-2 ethyl (E)-3-(thiophen-2-yl)acrylate 
• 690223-65-5 (+)-(2R,3R)-3-azido-3-thiophen-2-yl-propane-1,2-diol 
• 690223-63-3 (-)-(2S,3S)-2,3-dihydroxy-3-thiophen-2-yl-propionic acid ethyl ester 
• 690223-64-4 ethyl 2-oxo-5-thiophen-2-yl-2λ4-[1,3,2]dioxathiolane-4-carboxylic acid ethyl ester 
• 690223-62-2 (+)-(2S,3R)-3-azido-2-hydroxy-3-thiophen-2-yl-propionic acid ethyl ester 
• 690223-66-6 (+)-(2R,3R)-2,4,6-trimethyl-benzenesulfonic acid 3-azido-2-hydroxy-3-thiophen-2-yl-propyl ester 
• 690223-67-7 (-)-(3S,4aS,8aS,2'R,3'R)-[3'-azido-2'-hydroxy-3'-(thiophen-2-yl)-propyl]-decahydro-isoquinoline-3-carboxylic acid tert-butylamide 
• 861437-05-0 (+)-(2R,3R)-toluene-4-sulfonic acid 3-azido-2-hydroxy-3-thiophen-2-yl-propyl ester 

Relevant academic research and scientific papers

Synthesis of a first thiophene containing analog of the HIV protease inhibitor nelfinavir

A stereoselective and efficient preparation of a thiophene containing intermediate 2 from ethyl 3-thienyl propenoate 4 as the core of new possible HIV protease inhibitors is described. The chiral intermediate has been successfully used for the preparation

Synthesis, biological activity and modelling studies of two novel anti HIV PR inhibitors with a thiophene containing hydroxyethylamino core

An efficient method has been developed for the synthesis of a versatile intermediate bearing azido, hydroxyl and ester functions, a useful precursor for peptidomimetic compounds. The two main features for this synthesis were the use of the Sharpless asymm