69026-10-4Relevant articles and documents
Non-natural macrocyclic inhibitors of histone deacetylases: Design, synthesis, and activity
Auzzas, Luciana,Larsson, Andreas,Matera, Riccardo,Baraldi, Annamaria,Deschênes-Simard, Benoit,Giannini, Giuseppe,Cabri, Walter,Battistuzzi, Gianfranco,Gallo, Grazia,Ciacci, Andrea,Vesci, Loredana,Pisano, Claudio,Hanessian, Stephen
supporting information; experimental part, p. 8387 - 8399 (2011/02/23)
Nonpeptidic chiral macrocycles were designed on the basis of an analogue of suberoylanilide hydroxamic acid (2) (SAHA, vorinostat) and evaluated against 11 histone deacetylase (HDAC) isoforms. The identification of critical amino acid residues highly cons