69026-10-4Relevant academic research and scientific papers
Non-natural macrocyclic inhibitors of histone deacetylases: Design, synthesis, and activity
Auzzas, Luciana,Larsson, Andreas,Matera, Riccardo,Baraldi, Annamaria,Deschênes-Simard, Benoit,Giannini, Giuseppe,Cabri, Walter,Battistuzzi, Gianfranco,Gallo, Grazia,Ciacci, Andrea,Vesci, Loredana,Pisano, Claudio,Hanessian, Stephen
supporting information; experimental part, p. 8387 - 8399 (2011/02/23)
Nonpeptidic chiral macrocycles were designed on the basis of an analogue of suberoylanilide hydroxamic acid (2) (SAHA, vorinostat) and evaluated against 11 histone deacetylase (HDAC) isoforms. The identification of critical amino acid residues highly cons
A practical and convenient synthesis of methyl 5-formyl-3-methoxybenzoate
Zhao,Thurkauf
, p. 1921 - 1926 (2007/10/03)
A practical and convenient synthesis of methyl 5-formyl-3-methoxybenzoate starting from 3-hydroxy-5-(methoxycarbonyl)benzoate in 65% overall yield is described. Ethyl 5-formyl-3-methoxybenzoate was also prepared in the similar manner.
