69038-47-7

Basic information

• Product Name: L-Leucine, N-[1-[(1,1-dimethylethoxy)carbonyl]-L-prolyl]-, phenylmethyl ester
• CAS NO: 69038-47-7
• Molecular Formula: C23H34N2O5
• Molecular Weight: 418.533
• Mol File: 69038-47-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: L-Leucine, N-[1-[(1,1-dimethylethoxy)carbonyl]-L-prolyl]-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Leucine, N-[1-[(1,1-dimethylethoxy)carbonyl]-L-prolyl]-, phenylmethyl ester(69038-47-7)
• EPA Substance Registry System: L-Leucine, N-[1-[(1,1-dimethylethoxy)carbonyl]-L-prolyl]-, phenylmethyl ester(69038-47-7)

Safety Data

• Hazardous Substances Data: 69038-47-7(Hazardous Substances Data)

Upstream product

• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 87746-56-3 2-tert-butoxycarbonylamino-4-methyl-penatnoic acid benzyl ester 
• 1738-77-8 L-leucine benzyl ester p-toluenesulfonate 
• 1738-69-8 L-Leucine benzyl ester 

Downstream Products

• 66854-46-4 Pro-Leu-OBzl 
• 162457-70-7 Boc-Gly-Pro-Leu-OBzl 
• 162457-72-9 Boc-Leu-Gly-Pro-Leu-OBzl 
• 2873-36-1 cyclo(L-Pro-L-Leu) 

Relevant articles and documents

Solution-phase automated synthesis of tripeptide derivatives

An improved general method for automated synthesis of tripeptides was developed, in which methanesulfonic acid (MSA) was used in place of trifluoroacetic acid (TFA), thus making it possible to avoid, 1) corrosion of the apparatus by strong acid vapor, 2) formation of emulsions, and 3) use of the restricted solvent, dichloromethane. As an application of the automated synthesis apparatus, 216 fragment tripeptide derivatives were synthesized systematically using the MSA method, in excellent yield and with increased efficiency.

1-(o-NITROPHENYLSULPHONYLOXY)BENZOTRIAZOLE, REAGENT FOR THE CONDENSATION OF CARBOXYLIC ACIDS WITH AMINES

With the Schotten-Baumann reaction we have synthesized 1-(o-nitrophenylsulfonyloxy)benzotriazole and have shown its suitability for the synthesis of esters of 1-hydroxybenzotriazole and carboxylic amides, and also of peptides.