69045-48-3Relevant academic research and scientific papers
Chelation-Assisted Rhodium-Catalyzed Direct Amidation with Amidobenziodoxolones: C(sp2)-H, C(sp3)-H, and Late-Stage Functionalizations
Hu, Xu-Hong,Yang, Xiao-Fei,Loh, Teck-Peng
, p. 5930 - 5934 (2016)
Air-stable and convenient amidobenziodoxolones as an amidating reagent were disclosed to enable direct amidation on a wide range of C(sp2)-H bonds of (hetero)arenes and alkenes, as well as unactivated C(sp3)-H bonds under RhIII catalysis. The approach to access 49 examples of structurally diverse amides is featured by mild conditions, complete chemoselectivity and regioselectivity, broad substrate scope (not limited to strongly heterocyclic coordinating groups), and tolerance of valuable functional substituents, such as unprotected amine and hydroxyl groups. The synthetic applicability of this protocol is also demonstrated by late-stage functionalization of biologically important scaffolds.
RuHCl(CO)(PPh3)3-Catalyzed Direct Amidation of Arene C-H Bond with Azides
Xiao, Xinsheng,Jia, Guokai,Liu, Fang,Ou, Guangchuan,Xie, Ying
, p. 13811 - 13820 (2018/11/23)
We first report the direct ortho C-H amidation of arenes with azides by using a novel and inexpensive RuHCl(CO)(PPh3)3 catalyst. The reaction proceeds efficiently in high yield over a broad range of substrates without requirement of any additional silver salt or additive.
Rhodium-catalyzed direct C-H amidation of azobenzenes with sulfonyl azides: A synthetic route to sterically hindered ortho-substituted aromatic azo compounds
Jia, Xuefeng,Han, Jie
, p. 4180 - 4185 (2014/05/20)
A rhodium(III)-catalyzed direct ortho-amidation of azobenzenes with sulfonyl azides as the amino source is disclosed. This reaction exhibits a broad substrate scope, high functional group tolerance, and regioselectivity, providing a variety of sterically hindered ortho-substituted azobenzene derivatives in good to excellent yield.
