690629-98-2

Upstream product

• 92-48-8 6-methylcoumarin 
• 300767-38-8 2-[(Z)-3-{[1-(tert-butyl)-1,1-dimethyl-silanyl]oxy}-1-propenyl]-4-methylphenol 
• 51765-10-7 2-[(Z)-3-hydroxy-1-propenyl]-4-methylphenol 
• 690629-94-8 1-O-(N-Boc-D-leucyl)-2-[(Z)-3-(1-tert-butyl-1,1-dimethylsilyloxy)-1-propenyl]-4-methylphenol 

Downstream Products

• 690630-10-5 (R)-2-tert-Butoxycarbonylamino-4-methyl-pentanoic acid 2-{(Z)-2-[(S)-1-((R)-1-{[((S)-1-tert-butoxycarbonyl-2-phenyl-ethylcarbamoyl)-methyl]-carbamoyl}-ethylcarbamoyl)-2-(4-hydroxy-phenyl)-ethylcarbamoyl]-vinyl}-4-methyl-phenyl ester 
• 690630-06-9 (Z)-3-[2-(1-N-Boc-D-leucyl)-4-methylphenyl]-2-propenoic acid 
• 690630-02-5 1-O-(N-Boc-D-leucyl)-4-methyl-2-[(Z)-3-oxo-1-propenyl]phenol 

Relevant academic research and scientific papers

The effect of substitution patterns on the release rates of opioid peptides DADLE and [Leu5]-enkephalin from coumarin prodrug moieties

A coumarin-based prodrug system has been developed in our laboratory for the preparation of esterase-sensitive prodrugs of amines, peptides, and peptidomimetics. The drug release rates from this prodrug system were found to be dependent on the structural