690632-05-4 Usage
Description
TERT-BUTYL 6-BROMO-4-OXO-3,4-DIHYDRO-1'H-SPIRO[1,3-BENZOXAZINE-2,4'-PIPERIDINE]-1'-CARBOXYLATE is a complex organic compound characterized by its molecular formula C20H26BrNO4. It features a unique spirocyclic structure that includes both benzoxazine and piperidine ring systems. TERT-BUTYL 6-BROMO-4-OXO-3,4-DIHYDRO-1'H-SPIRO[1,3-BENZOXAZINE-2,4'-PIPERIDINE]-1'-CARBOXYLATE is known for its potential pharmacological properties and is commonly utilized in the fields of organic synthesis and medicinal chemistry research.
Used in Organic Synthesis:
TERT-BUTYL 6-BROMO-4-OXO-3,4-DIHYDRO-1'H-SPIRO[1,3-BENZOXAZINE-2,4'-PIPERIDINE]-1'-CARBOXYLATE is used as a key intermediate in organic synthesis for the development of new chemical entities. Its complex structure and functional groups make it a valuable building block for creating novel compounds with diverse applications.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, TERT-BUTYL 6-BROMO-4-OXO-3,4-DIHYDRO-1'H-SPIRO[1,3-BENZOXAZINE-2,4'-PIPERIDINE]-1'-CARBOXYLATE is employed as a potential pharmacological agent. Its unique structure and properties allow researchers to explore its interactions with biological targets, which may lead to the discovery of new therapeutic agents.
Used in Pharmaceutical Industry:
TERT-BUTYL 6-BROMO-4-OXO-3,4-DIHYDRO-1'H-SPIRO[1,3-BENZOXAZINE-2,4'-PIPERIDINE]-1'-CARBOXYLATE is used as a precursor in the synthesis of pharmaceutical compounds. Its presence in the molecular structure can contribute to the desired pharmacological effects, making it a valuable component in the development of new drugs.
Used in Chemical Research and Development:
In the realm of chemical research and development, TERT-BUTYL 6-BROMO-4-OXO-3,4-DIHYDRO-1'H-SPIRO[1,3-BENZOXAZINE-2,4'-PIPERIDINE]-1'-CARBOXYLATE is utilized as a subject of study to understand its reactivity, stability, and potential applications. This knowledge can be applied to improve existing processes or create new ones, enhancing the efficiency and effectiveness of chemical production.
Check Digit Verification of cas no
The CAS Registry Mumber 690632-05-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,9,0,6,3 and 2 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 690632-05:
(8*6)+(7*9)+(6*0)+(5*6)+(4*3)+(3*2)+(2*0)+(1*5)=164
164 % 10 = 4
So 690632-05-4 is a valid CAS Registry Number.
690632-05-4Relevant articles and documents
Synthesis and biological characterization of spiro[2H-(1,3)-benzoxazine-2, 4′-piperidine] based histone deacetylase inhibitors
Thaler, Florian,Varasi, Mario,Abate, Agnese,Carenzi, Giacomo,Colombo, Andrea,Bigogno, Chiara,Boggio, Roberto,Zuffo, Roberto Dal,Rapetti, Daniela,Resconi, Anna,Regalia, Nickolas,Vultaggio, Stefania,Dondio, Giulio,Gagliardi, Stefania,Minucci, Saverio,Mercurio, Ciro
, p. 273 - 284 (2013/07/27)
Histone Deacetylases (HDACs) have become important targets for the treatment of cancer and other diseases. In previous studies we described the development of novel spirocyclic HDAC inhibitors based on the combination of privileged structures with hydroxamic acid moieties as zinc binding group. Herein, we report further explorations, which resulted in the discovery of a new class of spiro[2H-(1,3)-benzoxazine-2,4′-piperidine] derivatives. Several compounds showed good potency of around 100 nM and less in the HDAC inhibition assays, submicromolar IC50 values when tested against tumour cell lines and a remarkable stability in human and mouse microsomes. Two representative examples exhibited a good pharmacokinetic profile with an oral bioavailability equal or higher than 35% and one of them studied in an HCT116 murine xenograft model showing a robust tumour growth inhibition. In addition, the two benzoxazines were found to have a minor affinity for the hERG potassium channel compared to their corresponding ketone analogues.