690632-14-5

Basic information

• Product Name: TERT-BUTYL 4-(2-AMINOPHENOXY)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE
• Synonyms: BUTTPARK 99\57-84;4-(2'-AMINOPHENOXY)PIPERIDINE, N1-BOC PROTECTED;TERT-BUTYL 4-(2-AMINOPHENOXY)PIPERIDINE-1-CARBOXYLATE;TERT-BUTYL 4-(2-AMINOPHENOXY)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE;4-(2'-Aminophenoxy)piperidine, N1-BOC protected 97%;N1-BOC-4-(2''-AMINOPHENOXY)PIPERIDINE;tert-Butyl 4-(2-aminophenoxy)piperidine-1-carboxylate, 2-{[1-(tert-Butoxycarbonyl)piperidin-4-yl]oxy}aniline;1-Boc-4-(2-aminophenoxy)-piperidine
• CAS NO: 690632-14-5
• Molecular Formula: C₁₆H₂₄N₂O₃
• Molecular Weight: 292.37
• Mol File: 690632-14-5.mol
• Article Data: 2

Chemical Properties

• Melting Point: 71 °C
• Boiling Point: 421.2°C at 760 mmHg
• Flash Point: 208.6°C
• Appearance: /
• Density: 1.14g/cm³
• Vapor Pressure: 2.64E-07mmHg at 25°C
• Refractive Index: 1.552
• CAS DataBase Reference: TERT-BUTYL 4-(2-AMINOPHENOXY)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL 4-(2-AMINOPHENOXY)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE(690632-14-5)
• EPA Substance Registry System: TERT-BUTYL 4-(2-AMINOPHENOXY)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE(690632-14-5)

Safety Data

• Hazard Codes: T
• Statements: 25-36
• Safety Statements: 26-45
• Hazardous Substances Data: 690632-14-5(Hazardous Substances Data)

Usage

Uses

tert-Butyl 4-(2-aminophenoxy)piperidine-1-carboxylate is used as a reactant in the preparation of heteroaryl sulfonamides as Kv potassium channel blockers.

InChI:InChI=1/C16H24N2O3/c1-16(2,3)21-15(19)18-10-8-12(9-11-18)20-14-7-5-4-6-13(14)17/h4-7,12H,8-11,17H2,1-3H3

Upstream product

• 690632-03-2 4-(2-nitrophenoxy)-piperidine-1-carboxylic acid tert-butyl ester 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 
• 88-75-5 2-hydroxynitrobenzene 

Downstream Products

• 1378110-13-4 N-(2-(piperidin-4-yloxy)phenyl)pyridine-2-sulfonamide trifluoroacetate 
• 1378110-48-5 N-(2-(1-(6-methylbenzo[d]oxazol-2-yl)piperidin-4-yloxy)phenyl)-pyridine-2-sulfonamide 
• 1378110-08-7 N-(2-(piperidin-4-yloxy)phenyl)pyridine-2-sulfonamide trifluoroacetate 

Relevant articles and documents

DERIVATIVES OF HETEROARYLSULFONAMIDES, THEIR PREPARATION AND THEIR APPLICATION IN HUMAN THERAPY

The present invention concerns derivatives of heteroarylsulfonamides, notably as blockers of Kv potassium channels, and more particularly of channels Kv1.5, Kv4.3 or Kv11.1, their application in clinical therapy and their preparation methods. These compounds correspond to the following general formula (I): where R1 represents one or more substituents of the phenyl core X such as: hydrogen, halogen, trifluoromethyl, trifluoromethoxy, linear or branched C1-C4 alkyl, or linear or branched C1-C4 alkoxy, A represents oxygen or sulphur, B represents nitrogen when n=1 or 2 and D represents —C(═O)—, or B represents CH when n=0 and D represents —CH2O— or when n=1 and D represents —O—, R2 represents a hydrogen, a methyl, a fluorine or chlorine atom or a methoxy, HetAr represents a pyridyl or quinolyl group, possibly substituted by a group such as a linear or branched C1-C4 alkyl, a linear or branched C1-C4 alkoxy, a halogen, or a trifluoromethyl, and to their pharmaceutically acceptable salts.