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69066-00-8

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69066-00-8 Usage

Uses

2-Oxo-2-[[4-(trifluoromethyl)phenyl]amino]acetic Acid Ethyl Ester, is an intermediate for the synthesis of 2-Oxo-2-[[4-(trifluoromethyl)phenyl]amino]acetic Acid (O865080). It can also be used for the preparation of Oxanilates derivatives, used as chemical hybridizing agents for Wheat (Triticum aestivum L.).

Check Digit Verification of cas no

The CAS Registry Mumber 69066-00-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,9,0,6 and 6 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 69066-00:
(7*6)+(6*9)+(5*0)+(4*6)+(3*6)+(2*0)+(1*0)=138
138 % 10 = 8
So 69066-00-8 is a valid CAS Registry Number.

69066-00-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name ethyl 4'-(trifluoromethyl)oxanilate

1.2 Other means of identification

Product number -
Other names 2-Oxo-2-[[4-(trifluoromethyl)phenyl]amino]acetic Acid Ethyl Ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:69066-00-8 SDS

69066-00-8Downstream Products

69066-00-8Relevant articles and documents

OXALAMIDE HETEROBYCYCLIC COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY

-

Page/Page column 146, (2021/04/10)

This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes (STING). Said chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) STING activation (e.g., STING signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions containing the same as well as methods of using and making the same.

Tethered NHC Ligands for Stereoselective Alkyne Semihydrogenations

Pape, Felix,Teichert, Johannes F.

supporting information, p. 2470 - 2482 (2017/05/22)

A copper(I)-catalyzed semihydrogenation of internal alkynes has been developed. A variety of oxygen- and nitrogen-tethered N-heterocyclic carbene (NHC) complexes have been investigated, leading to a highly Z-selective transformation. The catalyst is generated from inexpensive copper(I) chloride in situ and allows catalytic semihydrogenation down to 10 bar H2.

Design, synthesis, and antiviral activity of entry inhibitors that target the CD4-binding site of HIV-1

Curreli, Francesca,Choudhury, Spreeha,Pyatkin, Ilya,Zagorodnikov, Victor P.,Bulay, Anna Khulianova,Altieri, Andrea,Kwon, Young Do,Kwong, Peter D.,Debnath, Asim K.

scheme or table, p. 4764 - 4775 (2012/07/28)

The CD4 binding site on HIV-1 gp120 has been validated as a drug target to prevent HIV-1 entry to cells. Previously, we identified two small molecule inhibitors consisting of a 2,2,6,6-tetramethylpiperidine ring linked by an oxalamide to a p-halide-substituted phenyl group, which target this site, specifically, a cavity termed "Phe43 cavity". Here we use synthetic chemistry, functional assessment, and structure-based analysis to explore variants of each region of these inhibitors for improved antiviral properties. Alterations of the phenyl group and of the oxalamide linker indicated that these regions were close to optimal in the original lead compounds. Design of a series of compounds, where the tetramethylpiperidine ring was replaced with new scaffolds, led to improved antiviral activity. These new scaffolds provide insight into the surface chemistry at the entrance of the cavity and offer additional opportunities by which to optimize further these potential-next- generation therapeutics and microbicides against HIV-1.

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