690660-55-0Relevant academic research and scientific papers
Enantioselective copper(I)-Catalyzed borylative aldol cyclizations of enone diones
Burns, Alan R.,Solana Gonzalez, Jorge,Lam, Hon Wai
supporting information, p. 10827 - 10831 (2013/01/15)
Pina colato? In the presence of a chiral CuI/bisphosphine complex and B2(pin)2, enone diones undergo diastereo- and enantioselective desymmetrization to deliver highly functionalized bicyclic products. The products can be
Enolate generation under hydrogenation conditions: catalytic aldol cycloreduction of keto-enones.
Huddleston, Ryan R,Krische, Michael J
, p. 1143 - 1146 (2007/10/03)
[reaction: see text] Formal heterolytic activation of elemental hydrogen under Rh catalysis enables the reductive generation of enolates from enones under hydrogenation conditions. Enolates generated in this fashion participate in catalytic C-C bond formation via carbonyl addition to aldehyde and, as demonstrated in this account, ketone partners. Notably, the use of appendant dione partners enables diastereoselective formation of cycloaldol products possessing 3-stereogenic centers, including 2-contiguous quaternary centers.
