690660-56-1Relevant academic research and scientific papers
Enolate generation under hydrogenation conditions: catalytic aldol cycloreduction of keto-enones.
Huddleston, Ryan R,Krische, Michael J
, p. 1143 - 1146 (2007/10/03)
[reaction: see text] Formal heterolytic activation of elemental hydrogen under Rh catalysis enables the reductive generation of enolates from enones under hydrogenation conditions. Enolates generated in this fashion participate in catalytic C-C bond formation via carbonyl addition to aldehyde and, as demonstrated in this account, ketone partners. Notably, the use of appendant dione partners enables diastereoselective formation of cycloaldol products possessing 3-stereogenic centers, including 2-contiguous quaternary centers.
