690662-94-3Relevant academic research and scientific papers
Structure-activity relationship for aryl and heteroaryl boronic acid inhibitors of hormone-sensitive lipase
Ebdrup, Soren,Jacobsen, Poul,Farrington, Anupma Dhanda,Vedso, Per
, p. 2305 - 2312 (2007/10/03)
A range of aryl and heteroaryl boronic acids were tested for their in vitro hormone-sensitive lipase inhibitory properties. (2-Benzyloxy-5-fluorophenyl) boronic acid, (2-benzyloxy-5-chlorophenyl)boronic acid and 5-bromothiophene-2- boronic acid were found to be the most potent HSL inhibitors with IC 50 values of 140, 17 and 350 nM, respectively.
Synthesis of sulfonyl chlorides of phenylboronic acids
Veds?, Per,Olesen, Preben H.,Hoeg-Jensen, Thomas
, p. 892 - 894 (2007/10/03)
Sulfonyl chlorides of phenylboronic esters have been made available by selective lithiation of bromo N-methyl-diethanolamine phenylboronates to give lithium sulfinyl phenylboronates as intermediates. Oxidations with N-chlorosuccinimide give the target sul
HALO SULFONYL ARYL BORONATES
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Page 12, (2010/02/07)
The present invention relates to halo sulfonyl aryl boronates of the general formula (I): wherein Arylene designates a carbocyclic or heterocyclic, aromatic ring system comprising 1-3 rings; R1, R2 and R3 are, independently, hydrogen, C1-6alkyl, C1-6alkoxy, halogen, nitro, cyano or phenyl;X is fluoro, chloro or bromo; and Y is a boroxine moiety attached via a bond from Arylene to one of the boron atoms of a boroxine ring which ring has a group of the formula -Arylene(R1)(R2)(R3)SO2X, wherein Arylene, R1, R2, R3 and X are as defined above, at each of the other two boron atoms of the boroxine ring, or Y is a boronic acid group or a boronic ester group.The invention also relates to the preparation of the compounds of formula (I) and to their use in organic synthesis.
Halo sulfonyl aryl boronates
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Page 6, (2010/02/07)
The present invention relates to halo sulfonyl aryl boronates of the general formula (I): wherein Arylene designates a carbocyclic or heterocyclic, aromatic ring system comprising 1-3 rings; R1, R2 and R3 are, independentl
