69076-57-9

Usage

Molecular weight

324.37 g/mol

Classification

sulfonamide

Function

carbonic anhydrase inhibitor

Used for

treatment of glaucoma and ocular hypertension

Administration

eye drops

Common side effects

burning or stinging in the eye, blurred vision, bitter taste in the mouth

Safety and effectiveness

considered safe and effective for controlling intraocular pressure

Upstream product

• 85-44-9 phthalic anhydride 
• 108-69-0 3,5-dimethylaminoaniline 

Downstream Products

• 40101-45-9 2-(3,5-dimethylphenyl)isoindoline-1,3-dione 
• 403798-56-1 2-(3,5-dimethylphenyl)-3-hydroxyisoindolin-1-one 

Relevant academic research and scientific papers

Aza-DielsAlder reaction between N-aryl-1-oxo-1H-isoindolium ions and tert-enamides: Steric effects on reaction outcome

The synthesis of 5-substituted 6,6a-dihydroisoindolo[2,1-a]quinolin-11(5H)- ones via [4 + 2] imino-DielsAlder cyclization from N-aryl-3- hydroxyisoindolinones and N-vinyl lactams under Lewis acid-catalysed anhydrous conditions is reported. Reactions of N-(2-substituted-aryl)-3- hydroxyisoindolinones with N-vinylpyrrolidone under identical conditions resulted in the formation of 2-(2-substitued-aryl)-3-(2-(2-oxopyrrolidin-1-yl) vinyl)isoindolin-1-one analogues indicating steric hinderance as the cause of deviation. The probable mechanism of the reaction based on the results from X-ray crystallography and molecular modelling is discussed.