69088-98-8Relevant academic research and scientific papers
Compounds and their use in medicine, process for their preparation and pharmaceutical compositions containing them
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Page 25, (2008/06/13)
The present invention relates to novel antidiabetic, hypolipidemic, antiobesity and hypocholesterolemic compounds of formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them.
Amides of aminoalkyl-substituted azetidines, pyrrolidines, piperidines and azepanes
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, (2008/06/13)
Novel amides of aminoalkyl-substituted azetidines, pyrrolidines, piperidines and azepanes, use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds, and a method of treatment employing these compounds and compositions. The compounds show a high and selective binding affinity to the histamine H3 receptor indicating histamine H3 receptor antagonistic, inverse agonistic or agonistic activity. As a result, the compounds are useful for the treatment of diseases and disorders related to the histamine H3 receptor.
Synthesis of N1,4-Di(p-coumaroyl)spermine, a possible biogenetic precursor of aphelandrine
Veznik, Frantisek,Guggisberg, Armin,Hesse, Manfred
, p. 654 - 661 (2007/10/02)
Coupling of two differently substituted 1,3-diaminopropane units 5 and 6 (Schemes 1 and 2) lead to the key intermediate 8, a tetra-N-protected spermine derivative. By selective deprotection and alkylation with (E)-4-(mesy1oxy) cinnamoyl chloride, followed
