690993-87-4Relevant academic research and scientific papers
Fluorescent metal ion indicators based on benzoannelated crown systems: A green fluorescent indicator for intracellular sodium ions
Martin, Vladimir V.,Rothe, Anca,Gee, Kyle R.
, p. 1851 - 1855 (2005)
The synthesis and metal binding properties of cation-sensitive fluorescent indicators intended for biological applications are described. The increase of the crown ether ring size enhances the affinity for larger cations, but weakens the fluorescent response and selectivity. A compound having a 15-crown-5 chelator directly attached to a 2,7-difluoroxanthenone fluorophore loads into live cells and responds to sodium ion concentration changes with large fluorescence increases in the visible wavelength range.
