691012-71-2Relevant academic research and scientific papers
Convergent approach to the maduropeptin chromophore: Aryl ether formation of (R)-3-aryl-3-hydroxypropanamide and cyclization of macrolactam
Kato, Nobuki,Shimamura, Satoshi,Khan, Safraz,Takeda, Fumiyo,Kikai, Yoko,Hirama, Masahiro
, p. 3161 - 3172 (2007/10/03)
Efficient enantioselective syntheses of the functionalized phenol and diethynylcyclopentene moiety of the maduropeptin chromophore were achieved. Their CsF-mediated coupling yielded a sterically congested aryl propargyl ether. The subsequent intramolecular Sonogashira coupling reaction between the vinyl iodide and diethynyl groups occurred at the appropriate position to yield a macrolactam, which was accompanied by Pd-mediated enyne-yne benzannulation.
