691012-78-9

Basic information

• Product Name: (R)-3-(2-Chloro-3-hydroxy-4-methoxy-phenyl)-3-hydroxy-N-[(E)-3-iodo-4-(4-methoxy-benzyloxy)-but-2-enyl]-propionamide
• Synonyms: (R)-3-(2-Chloro-3-hydroxy-4-methoxy-phenyl)-3-hydroxy-N-[(E)-3-iodo-4-(4-methoxy-benzyloxy)-but-2-enyl]-propionamide
• CAS NO: 691012-78-9
• Molecular Weight: 561.801
• Mol File: 691012-78-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-3-(2-Chloro-3-hydroxy-4-methoxy-phenyl)-3-hydroxy-N-[(E)-3-iodo-4-(4-methoxy-benzyloxy)-but-2-enyl]-propionamide(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-(2-Chloro-3-hydroxy-4-methoxy-phenyl)-3-hydroxy-N-[(E)-3-iodo-4-(4-methoxy-benzyloxy)-but-2-enyl]-propionamide(691012-78-9)
• EPA Substance Registry System: (R)-3-(2-Chloro-3-hydroxy-4-methoxy-phenyl)-3-hydroxy-N-[(E)-3-iodo-4-(4-methoxy-benzyloxy)-but-2-enyl]-propionamide(691012-78-9)

Safety Data

• Hazardous Substances Data: 691012-78-9(Hazardous Substances Data)

Upstream product

• 691012-72-3 2-[(E)-3-Iodo-4-(4-methoxy-benzyloxy)-but-2-enyl]-isoindole-1,3-dione 
• 691012-70-1 tert-butyl-[3-iodo-4-(4-methoxy-benzyloxy)-but-2-enyloxy]-dimethyl-silane 
• 691012-74-5 3-(tert-butyl-dimethyl-silanyloxy)-2-chloro-4-methoxy-benzaldehyde 
• 37687-57-3 2-chloro-3-hydroxy-4-methoxybenzaldehyde 
• 691012-77-8 3-[3-(tert-butyl-dimethyl-silanyloxy)-2-chloro-4-methoxy-phenyl]-3-hydroxy-N-[3-iodo-4-(4-methoxy-benzyloxy)-but-2-enyl]-propionamide 

Downstream Products

• 691012-82-5 3-(3-{1-[1,5-bis-(tert-butyl-dimethyl-silanyloxy)-2-ethynyl-cyclopent-2-enyl]-prop-2-ynyloxy}-2-chloro-4-methoxy-phenyl)-3-(tert-butyl-dimethyl-silanyloxy)-N-[3-iodo-4-(4-methoxy-benzyloxy)-but-2-enyl]-propionamide 
• 691012-87-0 (R)-3-{2-Chloro-3-[(R)-1-((1S,5R)-2-ethynyl-1,5-dihydroxy-cyclopent-2-enyl)-prop-2-ynyloxy]-4-methoxy-phenyl}-3-hydroxy-N-[(E)-3-iodo-4-(4-methoxy-benzyloxy)-but-2-enyl]-propionamide 

Relevant articles and documents

Convergent approach to the maduropeptin chromophore: Aryl ether formation of (R)-3-aryl-3-hydroxypropanamide and cyclization of macrolactam

Efficient enantioselective syntheses of the functionalized phenol and diethynylcyclopentene moiety of the maduropeptin chromophore were achieved. Their CsF-mediated coupling yielded a sterically congested aryl propargyl ether. The subsequent intramolecular Sonogashira coupling reaction between the vinyl iodide and diethynyl groups occurred at the appropriate position to yield a macrolactam, which was accompanied by Pd-mediated enyne-yne benzannulation.