69114-72-3Relevant academic research and scientific papers
Structural factors affecting cytotoxic activity of (E)-1-(Benzo[d ][1,3]oxathiol-6-yl)-3-phenylprop-2-en-1-one derivatives
Konieczny, Marek T.,Bulakowska, Anita,Polak, Justyna,Pirska, Danuta,Konieczny, Wojciech,Gryn, Patrycja,Skladanowski, Andrzej,Sabisz, Michal,Lemke, Krzysztof,Pieczykolan, Anna,Galazka, Marlena,Wiciejowska, Katarzyna,Wietrzyk, Joanna
, p. 86 - 91 (2014/07/07)
Derivatives of (E)-1-(5-alkoxybenzo[d][1,3]oxathiol-6-yl)-3-phenylprop-2- en-1-one demonstrated exceptionally high in vitro cytotoxic activity, with IC50 values of the most active derivatives in the nanomolar range. To identify structural fragm
ISOXAZOLE DERIVATIVE HAVING AGONISTIC ACTIVITY AGAINST PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR
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Page/Page column 109, (2010/11/23)
A compound of formula (I) : (wherein R1-R10 are each independently hydrogen, halogen, optionally substituted lower alkyl or the like, X1 is -O-, -S-, -NR11- (wherein R11 is hydrogen, lower alkyl or the like), -CR12R13CO-, -(CR12R13)mO-, -O(CR12R13)m- (wherein R12 and R13 are each independently hydrogen or lower alkyl and m is a integer between 1 and 3) or the like, X2 is a bond, -O-, -S-, -NR14- (wherein R14 is hydrogen, lower alkyl or the like, R14 and R6 can be taken together with the neighboring atom to form a ring) or -CR15R16-(wherein R15 and R16 are each independently hydrogen or lower alkyl, R15 and R6 or R10 can be taken together with the neighboring carbon atom to form a ring, R16 and R9 can be joined together to form a bond), X3 is COOR17, C( = NR17)NR18OR19 or the like), a pharmaceutically acceptable salt or a solvate thereof.
Aryl-substituted acrylamides with Leukotriene B4 (LTB-4) receptor antagonist activity
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, (2008/06/13)
Disclosed are compounds of formula (I) wherein W is CH or N; R is (mono- or di cabocyclic or heterocyclic aryl)-lower alkyl; R1is hydrogen or lower alkyl; R2and R3are hydrogen, lower alkyl, lower alkoxy-lower alkyl or aryl
Carboxy-substituted cinnamides: A novel series of potent, orally active LTB4 receptor antagonists
Greenspan, Paul D.,Fujimoto, Roger A.,Marshall, Paul J.,Raychaudhuri, Anil,Lipson, Kenneth E.,Zhou, Huanghai,Doti, Robert A.,Coppa, David E.,Zhu, Lijuan,Pelletier, Roberta,Uziel-Fusi, Susan,Jackson, Robert H.,Chin, Michael H.,Kotyuk, Bernard L.,Fitt, John J.
, p. 164 - 172 (2007/10/03)
A series of carboxy-substituted cinnamides were investigated as antagonists of the human cell surface leukotriene B4 (LTB4) receptor. Binding was determined through measurement of [3H]-LTB4 displacement from hum
