69141-46-4

Upstream product

• 499-44-5 hinokitiol 
• 98-59-9 p-toluenesulfonyl chloride 
• 69141-47-5 6-(1-methylethyl)-2-[[(4-methylphenyl)sulfonyl]oxy]-2,4,6-cycloheptatrien-1-one 
• 32659-57-7 2-hydroxy-7-iodo-4-isopropyltropone 
• 106021-17-4 2-tosyloxy-4-isopropyl-7-iodo-tropone 

Downstream Products

• 69141-47-5 6-(1-methylethyl)-2-[[(4-methylphenyl)sulfonyl]oxy]-2,4,6-cycloheptatrien-1-one 
• 90874-67-2 2-Amino-5-isopropyl-tropon 

Relevant academic research and scientific papers

Identification of 4-isopropyl-thiotropolone as a novel anti-microbial: Regioselective synthesis, NMR characterization, and biological evaluation

We have synthesized and separated tosylated thujaplicin isomers for the first time, and elucidated their structures using 1D, 2D-NMR techniques and X-ray crystallography. The tosylated isomers were used to synthesize 4-isopropyl-thiotropolone and 6-isopro

Fluxional sulfonyl derivatives of troponoids and colchicinoids

In what represents the first examples of fluxional sulfonyl derivatives, the tosyl group in the couple 4-isopropyltropone/6-isopropyltropone (3/4), the tosyl or mesyl groups in the couple colchicine/isocolchicine (5/6 or 7/8), and the tosyl group in the couples of colchicinoids 9/10 and 11/12, were observed to undergo thermally-induced shift between the two tropolone-like oxygen atoms, likely via a bipyramidal intermediate; recycling of tosylates or mesylates of biologically inactive isocolchicinoids into the corresponding tosylates or mesylates of biologically active colchicinoids affords synthetic value to the unselective tosylation or mesylation of colchiceine.

New copper(II) 2-(alkylamino)troponates

The copper aminotropones Cu[ON(R′)C7H4R-4] 2 [R = H, R′ = Me (13), Et (14), n-Pr (15), n-Bu (16), Bz (17), MenOCH2CH2 (20); R = i-Pr, R′ = Me (18), n-Pr (19), MenOCH2CH2 (21)] have been prepared from the corresponding aminotropones HN(R′)OC7H4R-4 (1-7) by reacting with copper(II) acetate in aqueous ethanol. 20, 21 contain the flavourant, menthol, as part of the ligand. The structures of 5 (R = H, R′ = Bz), a hydrogen-bonded dimer, 14 and 20, both incorporating square-planar, four-coordinate copper centres, have been determined by X-ray crystallography. The antibacterial activities of complexes 13, 17, 20 and 21 have been assayed against Staphylococcus waneri, an in vitro model of plaque inhibition effects, and found to be more active than a commercial toothpaste formulation, but less active than the O,O-chelated copper(II) complex of ethylmaltol.

Tautomeric selectivity towards colchicinoids in the tosylation of colchiceine on a heterogeneous, easily removable catalyst.

Here is presented an easy, rapid new method of tosylation of compounds containing acidic OH groups, such as tropolones and phenols, on a solid, removable catalyst, Amberlite IRA-400(OH); of special value is the preferential selectivity for the colchiceine

Azulene derivatives and pharmaceutical compositions containing them

Azulene derivatives of the following formula STR1 wherein R1 stands for an alkyl group of 1 to 3 carbon atoms, R2 stands for an alkyl group of 1 to 3 carbon atoms, and R3 is at the 5- or 6-position and stands for an alkyl

Azulene derivatives and pharmaceutical compositions containing them

Azulene derivatives of the following formula STR1 wherein R1 stands for an alkyl group of 1 to 3 carbon atoms, R2 stands for an alkyl group of 1 to 3 carbon atoms, and R3 is at the 5- or 6- position and stands for an alkyl