691881-23-9

Basic information

• Product Name: 1-(2-cyclohexylimidazolidino[1,2-d]pyrazol-3-yl)-4-methylthiobenzene
• Synonyms: 1-(2-cyclohexylimidazolidino[1,2-d]pyrazol-3-yl)-4-methylthiobenzene
• CAS NO: 691881-23-9
• Molecular Weight: 313.467
• Mol File: 691881-23-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(2-cyclohexylimidazolidino[1,2-d]pyrazol-3-yl)-4-methylthiobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-cyclohexylimidazolidino[1,2-d]pyrazol-3-yl)-4-methylthiobenzene(691881-23-9)
• EPA Substance Registry System: 1-(2-cyclohexylimidazolidino[1,2-d]pyrazol-3-yl)-4-methylthiobenzene(691881-23-9)

Safety Data

• Hazardous Substances Data: 691881-23-9(Hazardous Substances Data)

Upstream product

• 691881-21-7 2-[5-amino-3-cyclohexyl-4-(4-methylthiophenyl)pyrazolyl]ethan-1-ol 
• 691881-20-6 3-cyclohexyl-2-(4-methylthiophenyl)-3-oxo-propanenitrile 
• 38746-92-8 2-[4-(methylsulfanyl)phenyl]acetonitrile 
• 3446-90-0 4-(methylthio)benzyl alcohol 
• 874-87-3 1-(chloromethyl)-4-methylthiobenzene 
• 691881-22-8 2-[5-amino-3-cyclohexyl-4-(4-methylthiophenyl)pyrazolyl]ethyl methylsulfonate 

Downstream Products

• 691881-28-4 [6-cyclohexyl-7-(4-methanesulfonyl-phenyl)-2,3-dihydro-imidazo[1,2-b]pyrazol-1-yl]-acetic acid tert-butyl ester 
• 691881-24-0 6-cyclohexyl-7-(4-methanesulfonyl-phenyl)-2,3-dihydro-1H-imidazo[1,2-b]pyrazole 
• 691881-27-3 tert-butyl 2-[2-cyclohexyl-3-(4-methylthiophenyl)imidazolidino[1,2-d]pyrazol-4-yl]acetate 

Relevant articles and documents

Synthesis and selective cyclooxygenase-2 (COX-2) inhibitory activity of a series of novel bicyclic pyrazoles

Novel series of pyrazolo[5,1-b]1,3-oxazolidines, pyrazolo[5,1-b]1,3- oxazines and imidazolidino[1,2-d]pyrazoles were synthesized. These compounds were evaluated in vitro for their ability to inhibit cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) in human whole blood (HWB). Several of the compounds were found to be novel and selective COX-2 inhibitors, the most potent and selective being 1-(5-cyclohexyl (2H,3H-pyrazolo[5,1-b]-1,3- oxazolidin-6-yl)-4-(methylsulfonyl)benzene, 7a (IC5o for COX-1>100 μM; for COX-2=1.3 μM).