69195-97-7

Usage

Uses

Used in Pharmaceutical Research:
2-NITRO-1-[5-NITRO-1-(PHENYLMETHYL)-1H-IMIDAZOL-4-YL] ETHANONE is used as a research compound for exploring its potential biological activity and medicinal properties due to its imidazole ring structure, which is commonly found in pharmaceuticals and biologically active molecules.
Used in Chemical Synthesis:
In the Chemical Synthesis Industry, 2-NITRO-1-[5-NITRO-1-(PHENYLMETHYL)-1H-IMIDAZOL-4-YL] ETHANONE is used as a precursor for synthesizing other nitrogen-containing compounds, leveraging its nitro groups and unique molecular structure.
Used in Nitric Oxide Research:
2-NITRO-1-[5-NITRO-1-(PHENYLMETHYL)-1H-IMIDAZOL-4-YL] ETHANONE is used as a potential nitric oxide donor in Nitric Oxide Research, where its ability to release nitric oxide could be studied for various physiological and pathological processes.

InChI:InChI=1/C12H10N4O5/c17-10(7-15(18)19)11-12(16(20)21)14(8-13-11)6-9-4-2-1-3-5-9/h1-5,8H,6-7H2

Upstream product

• 75-52-5 nitromethane 
• 69195-96-6 5-nitro-1-(phenylmethyl)-1H-imidazole-4-carboxylic acid 
• 857027-07-7 imidazolide 
• 530-62-1 1,1'-carbonyldiimidazole 
• 69195-95-5 1-benzyl-4-nitro-5-styryl-1H-imidazole 
• 434326-06-4 1-benzyl-4-dichloromethyl-5-nitroimidazole 
• 159790-78-0 1-benzyl-5-nitroimidazole 
• 100-44-7 benzyl chloride 
• 87471-10-1 5-nitro-1-(phenylmethyl)-1H-imidazole-4-carboxaldehyde 

Downstream Products

• 71222-44-1 6,7-dihydroimidazo<4,5-d><1,3>diazepin-8(3H)-one hydrochloride 
• 69196-01-6 3-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)-6,7-dihydroimidazo<4,5-d><1,3>diazepin-8(3H)-one 
• 69196-02-7 3-(2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl)-6,7-dihydroimidazo<4,5-d><1,3>diazepin-8(3H)-one 
• 53910-25-1 3-(2-deoxy-α-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo<4,5-d><1,3>diazepin-8-ol 
• 82228-59-9 (8R)-3-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo<4,5-d><1,3>diazepin-8-ol 
• 82228-60-2 (8S)-3-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo<4,5-d><1,3>diazepin-8-ol 
• 69195-91-1 2-amino-1-[5-amino-1-(phenylmethyl)-1H-imidazol-4-yl]ethanone dihydrochloride 

Relevant academic research and scientific papers

Vicarious nucleophilic substitution of 1-benzyl-5-nitroimidazole, application to the synthesis of 6,7-dihydroimidazo[4,5-d][1,3]diazepin-8(3H)-one

Reaction of 1-benzyl-5-nitroimidazole with carbanion generated from chloroform and potassium tert-butoxide afforded 1-benzyl-4-dichloromethyl-5-nitroimidazole in 72% yield. This vicarious nucleophilic substitution reaction was successfully applied to the synthesis of 6,7-dihydroimidazo[4,5-d][1,3]diazepin-8(3H)-one, an important intermediate in the synthesis of natural and biologically active compounds.

2-Amino-1-(5-amino-1H-imidazol-4-yl)ethanone and method of preparation

2-Amino-1-(5-amino-1H-imidazol-4-yl)ethanone, 6,7-dihydroimidazo[4,5-d][1,3]diazepin-8(3H)-one and acid-addition salts thereof are disclosed. 2-Amino-1-(5-amino-1H-imidazol-4-yl)ethanone and its acid-addition salts are prepared by catalytically reducing an acid-addition salt of 2-amino-1-[5-amino-1-(protected)-1H-imidazol-4-yl]ethanone. 6,7-Dihydroimidazo[4,5-d][1,3]-diazepin-8(3H)-one and its acid-addition salts are prepared by reacting an acid-addition salt of 2-amino-1-(5-amino-1H-imidazol-4-yl)ethanone with a compound able to contribute a formyl group. The later product may subsequently be converted into (R)-3-(2-deoxy-β-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol. Furanose derivatives of 6,7-dihydroimidazo[4,5-d][1,3]diazepine are also disclosed and their methods of preparation. Lastly, a method for resolving an isomer mixture of 3-(2-deoxy-β-D-erythro-pentafuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol compounds is related.