69196-03-8

Basic information

• Product Name: 8-ketodeoxycoformycin
• Synonyms: 8-ketodeoxycoformycin
• CAS NO: 69196-03-8
• Molecular Formula: C₁₁H₁₄N₄O₄
• Molecular Weight: 266.25326
• Mol File: 69196-03-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 658.6°C at 760 mmHg
• Flash Point: 352.1°C
• Appearance: /
• Density: 1.8g/cm³
• Vapor Pressure: 3.05E-18mmHg at 25°C
• Refractive Index: 1.793
• CAS DataBase Reference: 8-ketodeoxycoformycin(CAS DataBase Reference)
• NIST Chemistry Reference: 8-ketodeoxycoformycin(69196-03-8)
• EPA Substance Registry System: 8-ketodeoxycoformycin(69196-03-8)

Safety Data

• Hazardous Substances Data: 69196-03-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H14N4O4/c16-3-8-6(17)1-9(19-8)15-5-14-10-7(18)2-12-4-13-11(10)15/h4-6,8-9,16-17H,1-3H2,(H,12,13)/t6-,8+,9-/m0/s1

Upstream product

• 3601-90-9 5-chloro-2-(((4-chlorobenzoyl)oxy)methyl)tetrahydrofuran-3-yl 4-chlorobenzoate 
• 72079-77-7 6,7-dihydroimidazo<4,5-d><1,3>diazepin-8(3H)-one 
• 951-78-0 2'-deoxyuridine 
• 890-38-0 2-deoxyinosine 
• 856191-85-0 diazomethane diethyl ether 

Downstream Products

• 69196-04-9 (S)-pentostatin 
• 53910-25-1 2'-deoxycoformycin 

Relevant articles and documents

METHOD FOR THE SYNTHESIS OF PENTOSTATIN

The present invention relates to a method for the stereo-selective production of pentostatin comprising an enzymatic transglycosylation reaction between 6,7-dihydroimidazo-[4,5-d]-[1,3]diazepin-8(3H)-one and a 2'-deoxyribonucleoside, followed by an ruthenium-catalyzed asymmetric transfer hydrogenation.

Total synthesis of (8R)-3-(2-deoxy-β-D-erythro-pentofuranosyl)-3,6,7,8- tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol (pentostatin), the potent inhibitor of adenosine deaminase

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