69207-52-9Relevant academic research and scientific papers
The Baylis-Hillman chemistry in aqueous media: A convenient synthesis of 2-methylenealkanoates and alkanenitriles
Basavaiah, Deevi,Kumaragurubaran, Nagaswamy
, p. 477 - 479 (2007/10/03)
A convenient, general and efficient synthesis of 2-methylenealkanoates and alkanenitriles is accomplished via the regioselective nucleophilic (SN2′) addition of hydride ion from NaBH4 to (2Z)-2-(bromomethyl)alk-2-enoates and 2-(bromomethyl)alk-2-enenitriles respectively in the presence of DABCO in environment friendly aqueous media. Synthesis of two hypoglycemic agents is also described.
Alkylglycidic Acids: Potential New Hypoglycemic Agents
Ho, Winston,Tutwiler, Gene F.,Cottrell, Sandra C.,Morgans, Dave J.,Tarhan, Okan,Mohrbacher, Richard J.
, p. 2184 - 2190 (2007/10/02)
A series of alkylglycidic acid analogues and derivatives were synthesized and tested for their ability to inhibit long-chain fatty acid oxidation in vitro and to lower blood sugar in rats.The extent of inhibition of carnitine acyl transferase, the enzyme
Process for production of methyl 2-tetradecylgycidate
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, (2008/06/13)
An improved process for producing the hypoglycemic compound, methyl 2-tetradecylglycidate, by reacting methyl α-chloropalmitate with lithium methoxide in the presence of formaldehyde in a dipolar aprotic solvent such as DMF or DMSO.
