69209-40-1

Upstream product

• 1008-74-8 5-methyl-3-phenylisoxazole 
• 922-67-8 propynoic acid methyl ester 
• 66303-64-8 toluene-4-sulfonic acid 2-phenylallyl ester 
• 851762-31-7 2-(2-methyl-allyl)-4-phenyl-2-(toluene-4-sulfonyl)-pent-4-enoic acid methyl ester 
• 851762-21-5 4-methyl-2-(toluene-4-sulfonyl)-pent-4-enoic acid methyl ester 
• 851762-40-8 4-oxo-2-(2-oxo-2-phenyl-ethyl)-2-(toluene-4-sulfonyl)-pentanoic acid methyl ester 
• 1008-75-9 3-methyl-5-phenylisoxazole 

Relevant academic research and scientific papers

Sulfone-mediated synthesis of polysubstituted pyridines

Base-mediated and/or palladium(0)-catalysed bis(allylation) of alkyl 2-(tolylsulfonyl)acetates gives 1,6-dienes, which upon ozonolytic cleavage of the double bonds and ammonolysis give 2,6-disubstituted pyridine-4-carboxylic esters. Decarboxylation of one

Hexacarbonylmolybdenum-induced Reaction of Isoxazoles. Cycloaddition of Isoxazoles with Acetylenic Esters and Related Reactions

In the presence of hexacarbonylmolybdenum, substituted isoxazoles undergo a cycloaddition reaction with dimethyl acetylenedicarboxylate across the C-4-C-5 bond to give 3,4-bis(methoxycarbonyl)pyridine derivatives.In a similar cycloadition of isoxazoles with methyl propiolate, 4-(methoxycarbonyl)pyridine derivatives were also obtained.The β-carbon atom of methyl propiolate could intervene in the bonding with the C-5 position of the isoxazoles regioselectively.A mechanism involving a complexed 2-oxa-3-azabicyclohepta-3,6-diene derivative and the subsequent N-Oand C-1-C-5 bond cleavage leading to a complexed (β-ketovinyl)nitrene intermediate is proposed for the formation of pyridine derivatives.In order to clarify the mechanistic aspect, the reaction of 4-phenyl-2-oxa-3-azabicyclohepta-3,6-diene and its related compounds were also studied to give pyridine derivatives.