69219-24-5

Basic information

• Product Name: Osthol hydrate
• Synonyms: Osthol hydrate;8-(3-Hydroxy-3-methylbutyl)-7-methoxy-2H-1-benzopyran-2-one
• CAS NO: 69219-24-5
• Molecular Formula: C15H18O4
• Molecular Weight: 262.30102
• Product Categories: Coumarins
• Mol File: 69219-24-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Osthol hydrate(CAS DataBase Reference)
• NIST Chemistry Reference: Osthol hydrate(69219-24-5)
• EPA Substance Registry System: Osthol hydrate(69219-24-5)

Safety Data

• Hazardous Substances Data: 69219-24-5(Hazardous Substances Data)

Upstream product

• 484-12-8 osthole 

Relevant articles and documents

Main constituents from the seeds of Vietnamese Cnidium monnieri and cytotoxic activity

From the ethyl acetate extract of the seeds of Vietnamese Cnidium monnieri L., three coumarins, osthole (1), xanthotoxin (2), imperatorin (3) and a sterol, daucosterol (4) have been purified. Their structures were elucidated by spectroscopic analysis. Furthermore, 8-(3-hidroxy-3-methylbutyl)-7- methoxycoumarin (5) was synthesised from osthole (1) with a good yield (80%). In addition, compound 1 and its synthesis product (5) show moderate and non-selective cytotoxic activities against four cancer cells, KB (a human epidermal carcinoma), MCF7 (human breast carcinoma), SK-LU-1 (human lung carcinoma) and HepG2 (hepatocellular carcinoma).

Synthesis and biological evaluation of novel osthol derivatives as potent cytotoxic agents

Background: Natural product, osthol has been found to have important biological and pharmacological roles particularly having inhibitory effect on multiple types of cancer. Objective: The unmet needs in cancer therapeutics make its derivatization an impor