69231-87-4

Usage

Uses

Used in Pharmaceutical Industry:
1,1'-Biphenyl, 4-bromo-4'-(trifluoromethyl)is used as a reagent for the synthesis of glucagon receptor antagonists. These antagonists are important in the development of treatments for conditions such as diabetes and obesity, as they help regulate blood sugar levels and reduce appetite. 1,1'-Biphenyl, 4-bromo-4'-(trifluoromethyl)-'s unique structure allows for the creation of specific and potent glucagon receptor antagonists, contributing to the advancement of therapeutic options in these areas.

Upstream product

• 589-87-7 1,4-bromoiodobenzene 
• 128796-39-4 4-trifluoromethylphenylboronic acid 
• 398-36-7 1-phenyl-4-(trifluoromethyl)benzene 

Downstream Products

• 1383801-90-8 (tetrahydro-2H-pyran-4-yl)(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)methanol 
• 1381958-89-9 4,4,5,5-tetramethyl-2-(4'-(trifluoromethyl)-[1,1^,-biphenyl]-4-yl)-1,3,2-dioxaborolane 
• 1620166-28-0 C₆₆H₄₀F₁₂O₆P₂ 
• 1552318-75-8 C₂₅H₂₂F₃NO₂ 
• 90035-34-0 4-(4-trifluoromethylphenyl)benzaldehyde 
• 364590-93-2 (4'-(trifluoromethyl)-[1,1’-biphenyl]-4-yl)boronic acid 

Relevant academic research and scientific papers

PRODUCING METHOD OF MONO-COUPLING BODY

The present invention provides a producing method of a compound represented by the general formula (5): R1-Ar-X, which is characterized by bringing an aromatic compound represented by the general formula (1): R1-Ar-X' (in the formula, Ar, X and X', R1 has a definition the same as the specification and claims) into reaction with an organic boron compound represent by the general formula (2) to (4) in water and organic solvent, in the presence of water-soluble palladium and base. The producing method of this invention is capable of suppressing subgeneration of dicoupling body when providing a compound with two leaving groups to coupling reaction, and capable of selectively and easily obtain a mono-coupling body.

C-Aryl glucoside SGLT2 inhibitors containing a biphenyl motif as potential anti-diabetic agents

A series of highly active C-aryl glucoside SGLT2 inhibitors containing a biphenyl motif were designed and synthesized for biological evaluation. Among the compounds tested, compound 16l demonstrated high inhibitory activity against SGLT2 (IC50 = 1.9 nM) with an excellent pharmacokinetic profile. Further study indicated that the in vivo efficacy of compound 16l was comparable to that of dapagliflozin, suggesting that further development would be worthwhile.

Ni(II) catalyzed bromination of aryl C-H bonds

Bromination of unactivated aromatic C-H bonds without directing and/or chelating groups was achieved by employing an air stable N-heterocyclic Ni(II) complex. PhI(OAC)2 and N-bromosuccinimide have been used as the oxidizing agent and the bromin

Ni(II) catalyzed bromination of aryl C-H bonds

Bromination of unactivated aromatic C-H bonds without directing and/or chelating groups was achieved by employing an air stable N-heterocyclic Ni(II) complex. PhI(OAC)2and N-bromosuccinimide have been used as the oxidizing agent and the bromine source, respectively. Yields for bromination are as high as >99%, especially in presence of electron-withdrawing groups like -NO2and -CF3. This is a rare report on C-H bond activation with Ni(II) where, instead of homo C-C coupling, reductive elimination to form C-halogen could be achieved.

Glucagon Receptor Modulators

The present invention provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof wherein R1, R2, R3, A1, A2, A3, A4, L, B1, B2, B3 and B4 are as defined herein. The compounds of Formula I have been found to act as glucagon antagonists or inverse agonists. Consequently, the compounds of Formula I and the pharmaceutical compositions thereof are useful for the treatment of diseases, disorders, or conditions mediated by glucagon.

Photochemische Untersuchungen an Bis(phenyl)(diarsan)platin(II)-Verbindungen

The compounds (η2-diarsane)bis(phenyl)platinum(II) with either a CH3, (CH3)2CH, (CH3)3C, F, Br, CF3, (CH3)3Si in the 4-position of the platinum-bound phenyl rings have been synthesized and studied photochemically.After excitation into the longest wavelength absorption band they eliminate the two substituted, platinum-bound rings as a biphenyl, but are photo-stable when excited by shorter wavelength UV-radiation.The elimination is exclusively intramolecular and stereospecific; it is an example of a concerted pericyclic at a transition metal.