69256-20-8

Basic information

• Product Name: (Z)-(R)-3-(trityloxy)propane-1,2-diyl dioleate
• CAS NO: 69256-20-8
• Molecular Weight: 863.318
• Mol File: 69256-20-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (Z)-(R)-3-(trityloxy)propane-1,2-diyl dioleate(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-(R)-3-(trityloxy)propane-1,2-diyl dioleate(69256-20-8)
• EPA Substance Registry System: (Z)-(R)-3-(trityloxy)propane-1,2-diyl dioleate(69256-20-8)

Safety Data

• Hazardous Substances Data: 69256-20-8(Hazardous Substances Data)

Upstream product

• 112-77-6 (Z)-9-octadecenoyl chloride 
• 16975-62-5 tritylglycerol 
• 16975-61-4 (R)-2,2-dimethyl-4-trityloximethyl-[1,3]dioxolane 
• 112-80-1 cis-Octadecenoic acid 
• 17327-05-8 (S)-3-(trityloxy)propane-1,2-diol 
• 17327-06-9 (R)-4-(triphenylmethoxy)methyl-1,3-dioxolan-2-one 

Downstream Products

• 102916-98-3 (Z)-Octadec-9-enoic acid 2-[(2,4-dichloro-phenoxy)-hydroxy-phosphoryloxy]-1-((Z)-octadec-9-enoyloxymethyl)-ethyl ester; compound with triethyl-amine 

Relevant articles and documents

Synthesis of Phosphatidylserine and Its Stereoisomers: Their Role in Activation of Blood Coagulation

Natural phosphatidylserine (PS), which contains two chiral centers, enhances blood coagulation. However, the process by which PS enhanced blood coagulation is not completely understood. An efficient and flexible synthetic route has been developed to synthesize all of the possible stereoisomers of PS. In this study, we examined the role of PS chiral centers in modulating the activity of the tissue factor (TF)-factor VIIa coagulation initiation complex. Full length TF was relipidated with phosphatidylcholine, and the synthesized PS isomers were individually used to estimate the procoagulant activity of the TF-FVIIa complex via a FXa generation assay. The results revealed that the initiation complex activity was stereoselective and had increased sensitivity to the configuration of the PS glycerol backbone due to optimal protein-lipid interactions.

Synthesis of phosphatidyl-α-glucosyl-diacylglycerol containing palmitic and oleic acid esters

The recently introduced 1,3-dichloro-1,1,3,3-tetraisopropyldisiloxane protecting group enabled us to synthesize a naturally occurring phosphatidyl-α-glucosyl-diacylglycerol via a phosphotriester intermediate.