69257-04-1Relevant articles and documents
Preparation method of optically pure 1, 1'-spirobiindane-6, 6'-diol derivative
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Paragraph 0020-0022, (2019/03/17)
The invention discloses a preparation method of an optically pure 1, 1'-spirobiindane-6, 6'-diol derivative. The derivative is shown in the formula I. The optically pure 1, 1'-spirobiindane-6, 6'-diolderivative is prepared from optically pure N-benzylcinchonidinium chloride as an inclusion main body and a racemic 1, 1'-spirobiindane-6, 6'-diol derivative as a guest through an inclusion and resolution method. The novel method can acquire the 1, 1'-spirobiindane-6, 6'-diol derivative with high optical purity and chemical purity and acquire two structures in a high yield, has simple separation and purification processes, realizes recovery and recycling of a lot of a resolving agent, is simple and efficient, realizes a low cost and is suitable for industrial promotion. The optically pure 1, 1'-spirobiindane-6, 6'-diol derivative is a key raw material for the preparation of chiral spiro ligands or catalysts.
Asymmetric Induction in the Michael Reaction by Means of Chiral Phase-transfer Catalysts derived from Cinchona and Ephedra Alkaloids
Colonna, Stefano,Re, Alberto,Wynberg, Hans
, p. 547 - 552 (2007/10/02)
Asymmetric induction in the Michael reaction has been achieved using alkaloidonium salts in a two-phase system with optical yields of up to 36 and 26percent in the addition to αβ-unsaturated ketones of thiols and nitroalkanes respectively.The presence of a hydroxy-group β to the 'onium function is essential to achieve substantial asymmetric syntheses.