6926-55-2

Downstream Products

• 63503-52-6 2-<β-Hydroxy-ethylamino>-1,3,4-thiadiazol-5-thion 
• 928345-68-0 6-{3-(4-fluorophenyl)-5-[(2-hydroxyethyl)amino]-1H-pyrazol-4-yl}-2-(2-methylphenyl)pyridazin-3(2H)-one 

Relevant academic research and scientific papers

3-Thiovinyl-cephalosporins

Novel cephalosporins of the general formula (I); STR1 in which R is alkyl, L-2-amino-2-carboxy-ethyl, phenyl, pyridyl, pyridyl-N-oxide, pyrimidin-2-yl, substituted pyridazin-3-yl, 5,6-dioxo-1,4,5,6-tetrahydro-1,2,4-triazin-3-yl substituted in the 4-position, 1,3,4-triazol-5-yl or 2-alkoxycarbonyl-1,3,4-triazol-5-yl substituted in the 1-position, 1,4-dialkyl-5,6-dioxo-1,4,5,6-tetrahydro-1,2,4-triazin-3-yl, 1-alkyl-5,6-dioxo-1,4,5,6-tetrahydro-1,2,4-triazin-3-yl, 2-alkyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl, triazol-5-yl, 1,3,4-thiadiazol-5-yl which is substituted or unsubstituted, 1,2,4-thiadiazol-5-yl which is substituted, 1,3,4-oxadiazol-5-yl which is substituted or unsubstituted, oxazol-2-yl which is substituted or unsubstituted or tetrazol-5-yl which is substituted or unsubstituted in the 1-position, R' is a hydrogen atom or a radical of the general formula (II); STR2 and Ro is hydrogen, alkyl, vinyl or cyanomethyl, as well as their salts, are useful as anti-bacterial agents.

3-Vinyl-cephalosporins

Novel 3-vinyl-cephalosporins of the formula STR1 in which n is 0 or 1, R1 is hydrogen, a radical of the formula STR2 [in which R4 is hydrogen or a protective radical and R5 is hydrogen, alkyl, vinyl or cyanomethyl or is a protective radical], or a protective radical, and R2 is hydrogen, a protective radical or an enzymatically removable radical, or R1 is hydrogen or an acyl radical which may carry various substituents and R2 is hydrogen or a protective radical, and R3 is a radical of the general formula R'3 --SO2 --O-- or R"3 --CO--O--, in which R'3 is alkyl, trifluoromethyl, trichloromethyl or phenyl which is substituted by a halogen atom or by an alkyl or nitro radical, and R"3 is defined like R'3 or represents methyl which is substituted by acyl or alkoxycarbonyl, or represents ethyl or propyl substituted in the 2-position by acyl or alkoxycarbonyl. These compounds are useful as intermediates for the preparation of antibiotic 3-thiovinyl-cephalosporins.

3-Vinyl-cephalosporin derivatives

Novel 3-vinyl-cephalosporin derivates of the general formula STR1 in the bicyclooct-2-ene or bicyclooct-3-ene form, in which R1 is a protective radical or is a radical of the general formula STR2 in which R5 is hydrogen, alkyl, vinyl or cyanomethyl, or a protective radical, and R6 is hydrogen or a protective radical, and R2 is a protective radical or an enzymatically removable radical, or R1 is an acyl radical, which may carry various substituents, and R2 represents a protective radical, and R3 and R4, which are identical or different, represent alkyl (optionally substituted by hydroxyl, alkoxy, amino, alkylamino or dialkylamino) or phenyl, or form, together with the nitrogen atom, a saturated 5-membered or 6-membered heterocyclic ring optionally containing another hetero-atom, their E- and Z-forms and their mixtures, are useful as intermediates for the preparation of 3-thiovinyl cephalosporins useful as antibacterial agents.