69270-05-9Relevant academic research and scientific papers
SYNTHESES OF 1-PHENYL-2-(4(1H)-QUINAZOLINYLIDENE)ETHANONE AND RELATED ETHANONES.
Sund,Beall,Borgfeld
, p. 428 - 429 (2007/10/02)
Eleven 1-phenyl-2-(4(1H)-quinazolinylidene)ethanones were synthesized by the condensation of 4-methylquinazoline and the requiste methyl benzoate ester with sodium hydride as the condensing agent. Substitutents in the 3- or 4-positions of the phenyl ring were chloro, dimethylamino, methoxy, methyl, and trifluoromethyl.
N-Quaternary Heterocyclics : Part X- Acid-catalysed Transformation of 2-(4-Quinazolinylthio)ketones to 2-ketones and 2-(o-Aminophenyl)thiazoles
Singh, Harjit,Gandhi, C. S.,Bal, M. S.
, p. 17 - 20 (2007/10/02)
2-(4-Quinazolinylthio)acetophenones (IV) when treated with a small amount of conc. sulphuric acid at room temperature or polyphosphoric acid at 130-40 deg C undergo sulphur extrusion and in the presence of perchloric acid afford 4-phenacylquinazolinium perchlorates (V).However, with an excess of conc.H2SO4, 3-arylthiazoloquinazolinium perchlorates (I), are also formed.Compounds (IV) on heating with perchloric or hydrochloric acid furnish 2-(o-aminophenyl)thiazoles (II) in synthetically useful yields.
