692729-85-4Relevant academic research and scientific papers
Highly substituted pyridines via tethered imine-enamine (TIE) methodology
Raw, Steven A.,Taylor, Richard J. K.
, p. 508 - 509 (2004)
A tethered imine-enamine methodology has been developed for the direct conversion of 1,2,4-triazines into highly substituted pyridines via the inverse electron demand Diels-Alder reaction which avoids the need for a discrete aromatisation step. This TIE methodology has also been applied in one pot reaction cascades involving 1,2,4-triazines and utilising MnO 2-mediated tandem oxidation processes (TOPs).
Improved and practical procedures for the preparation of highly substituted pyridines and pyridazines via silica-mediated aromatisation
Catozzi, Nicola,Bromley, William J.,Wasnaire, Pierre,Gibson, Mairi,Taylor, Richard J. K.
, p. 2217 - 2221 (2008/02/10)
A new and straightforward procedure is described for the preparation of highly substituted pyridines and pyridazines. The method involves a Diels-Alder/retro-Diels-Alder sequence leading to dihydropyridine or related intermediates, which can be aromatized
Improved methodologies for the preparation of highly substituted pyridines
Sainz, Yolanda Fernandez,Raw, Steven A.,Taylor, Richard J. K.
, p. 10086 - 10095 (2007/10/03)
Two separate strategies have been developed for the preparation of highly substituted pyridines from 1,2,4-triazines via the inverse-electron-demand Diels-Alder reaction: a microwave-promoted, solvent-free procedure and a tethered imine-enamine (TIE) appr
