69300-14-7Relevant articles and documents
Indium(III) acetate-catalyzed intermolecular radical addition of organic iodides to electron-deficient alkenes
Miura, Katsukiyo,Tomita, Mitsuru,Ichikawa, Junji,Hosomi, Akira
, p. 133 - 136 (2008/09/16)
In the presence of phenylsilane and a catalytic amount of indium(III) acetate, organic iodides added to electron-deficient alkenes in ethanol at room temperature. Both simple and functionalized organic iodides were applicable to this reaction. A plausible reaction mechanism involves the formation of indium hydride species by hydride transfer from silicon to indium and an indium hydride-mediated radical chain process.
Synthetic radical reactions using dibutylchlorogermane and dibutylethoxygermane as radical mediators
Miura, Katsukiyo,Ootsuka, Kazunori,Hosomi, Akira
, p. 3151 - 3153 (2007/10/03)
In the presence of Et3B as radical initiator, dibutylchlorogermane (1a) and dibutylethoxygermane (1b) reacted with bromo- and iodoalkanes at room temperature to give the corresponding alkanes in high yields. Hydrogermane 1a was more reactive than 1b. However, 1b worked as a better radical mediator in intermolecular radical addition of haloalkanes to electron-deficient alkenes. Georg Thieme Verlag Stuttgart.
Hydrocarbon activation. Synthesis of β-cycloalkyl (Di)nitriles through photosensitized conjugate radical addition
Cardarelli,Fagnoni,Mella,Albini
, p. 7320 - 7327 (2007/10/03)
Photoinduced hydrogen abstraction from aliphatic cyclic hydrocarbons (C5 to C7, C12, as well as adamantane) by triplet aromatic ketones in the presence of α,β-unsaturated (di)nitriles offers a straightforward entry to the corresponding alkylated (di)nitriles via the alkyl radicals. Yields are moderate to good depending on the olefins structure (substitution in β slows down the addition to mononitriles, but with α,α-dinitriles electronic activation allows efficient alkylation also of β,β-disubstituted substrates). A tandem alkylation - cyclization process has been obtained with (1-methylpent-4-enylidene)malononitrile.
Synthesis and antiallergy activity of [1,3,4]thiadiazolo[3,2-a]-1,2,3-triazolo[4,5-d]pyrimidin-9(3H)-one derivatives. II. 6-Alkyl- and 6-cycloalkylalkyl derivatives
Yokohama,Miwa,Aibara,Fujiwara,Matsumoto,Nakayama,Iwamoto,Mori,Moroi,Tsukada,Isoda
, p. 2391 - 2398 (2007/10/02)
A series of 6-alkyl- or 6-(cycloalkylalkyl)-[1,3,4]thiadiazolo[3,2-a]-1,2,3-triazolo[4,5-d]pyr imidin-9(3H)-ones 1b-o was synthesized from the corresponding 1,3,4-thiadiazol-5-amines 3b-o and the antiallergic activities of the products were evaluated. Among the compounds 6-(2-cyclohexylethyl)-[1,3,4]thiadiazolo[3,2-a]-1,2,3-triazolo[4,5-d]p yrimidin-9(3H)-one 1h, whose X-ray crystallographic stereostructure is shown, was found to be a promising new antiallergic agent, which has low toxicity and dual activity as a leukotriene D4 receptor antagonist and as an orally active mast cell stabilizer.
