69300-19-2Relevant academic research and scientific papers
Palladium-Catalyzed α,β-Dehydrogenation of Esters and Nitriles
Chen, Yifeng,Romaire, Justin P.,Newhouse, Timothy R.
, p. 5875 - 5878 (2015/05/27)
A highly practical and general palladium-catalyzed methodology for the α,β-dehydrogenation of esters and nitriles is reported. Generation of a zinc enolate or (cyanoalkyl)zinc species followed by the addition of an allyl oxidant and a palladium catalyst results in synthetically useful yields of α,β-unsaturated esters, lactones, and nitriles. Preliminary mechanistic investigations are consistent with reversible β-hydride elimination and turnover-limiting, propene-forming reductive elimination.
One-pot Conversion of Allylic Nitro Compounds Into Nitriles with Carbon Disulphide under Phase-transfer Catalysis Conditions
Albanese, Domenico,Landini, Dario,Penso, Michele,Pozzi, Gianluca
, p. 965 - 971 (2007/10/02)
An one-pot synthesis of allylic nitriles 3 from the corresponding nitro derivatives 1 is described.In the first step the substrates 1 are reduced to the oximes 2 by carbon disulphide in the presence of wet potassium carbonate, in solid-liquid PTC conditions.In the second, the formed oximes 2 are dehydrated by adding more CS2 and 15percent aqueous NaOH.
