693228-22-7Relevant articles and documents
An efficient phosphine-free palladium coupling for the synthesis of new 2-arylbenzo[b]thiophenes
Dit Chabert, Jérémie Fournier,Joucla, Lionel,David, Emilie,Lemaire, Marc
, p. 3221 - 3230 (2004)
Straightforward and rapid access to 2-arylbenzo[b]thiophenes has been developed. It involved a catalytic coupling of 3-activated benzo[b]thiophenes with several aryl halides in the presence of a phosphine-free palladium system. In case of fragile functional groups such as aldehydes, a quaternary ammonium was used as an additive as with the other substrates, the coupling performed better and faster in the presence of a crown ether, the best one being DCH-18-C-6, with good yields and low reaction times. This method would provide a direct access to novel structures of biological interest.
Synthesis and evaluation of new arylbenzo[b]thiophene and diarylthiophene derivatives as inhibitors of the NorA multidrug transporter of Staphylococcus aureus
Fournier dit Chabert, Jeremie,Marquez, Beatrice,Neville, Luc,Joucla, Lionel,Broussous, Sylvie,Bouhours, Pascale,David, Emilie,Pellet-Rostaing, Stephane,Marquet, Bernard,Moreau, Nicole,Lemaire, Marc
, p. 4482 - 4497 (2008/03/13)
The synthesis based on palladium catalytic coupling of 38 new-arylated benzo[b]thiophenes or thiophenes is described in a few steps. We also report the direct arylation of the position 3 of the benzo[b]thiophenic structure, a 'one pot' 2,5-heterodiarylati