693228-22-7Relevant academic research and scientific papers
An efficient phosphine-free palladium coupling for the synthesis of new 2-arylbenzo[b]thiophenes
Dit Chabert, Jérémie Fournier,Joucla, Lionel,David, Emilie,Lemaire, Marc
, p. 3221 - 3230 (2004)
Straightforward and rapid access to 2-arylbenzo[b]thiophenes has been developed. It involved a catalytic coupling of 3-activated benzo[b]thiophenes with several aryl halides in the presence of a phosphine-free palladium system. In case of fragile functional groups such as aldehydes, a quaternary ammonium was used as an additive as with the other substrates, the coupling performed better and faster in the presence of a crown ether, the best one being DCH-18-C-6, with good yields and low reaction times. This method would provide a direct access to novel structures of biological interest.
Scaleable preparation of sensitive functionalized aromatics and heteroaromatics via directed metalation using tmpZnCl.LiCl
Bresser, Tomke,Monzon, Gabriel,Mosrin, Marc,Knochel, Paul
experimental part, p. 1299 - 1303 (2011/09/20)
A range of functional aryl and heteroaryl zinc reagents were prepared in THF via directed zincation using the previously reported amide base tmpZnCl.LiCl. These metalation reactions were carried out on 50 mmol scale. Diverse sensitive functional groups su
Synthesis and evaluation of new arylbenzo[b]thiophene and diarylthiophene derivatives as inhibitors of the NorA multidrug transporter of Staphylococcus aureus
Fournier dit Chabert, Jeremie,Marquez, Beatrice,Neville, Luc,Joucla, Lionel,Broussous, Sylvie,Bouhours, Pascale,David, Emilie,Pellet-Rostaing, Stephane,Marquet, Bernard,Moreau, Nicole,Lemaire, Marc
, p. 4482 - 4497 (2008/03/13)
The synthesis based on palladium catalytic coupling of 38 new-arylated benzo[b]thiophenes or thiophenes is described in a few steps. We also report the direct arylation of the position 3 of the benzo[b]thiophenic structure, a 'one pot' 2,5-heterodiarylati
